康艾注射液对肝癌患者TACE术后生活质量的影响

Observation of Kang' ai- injection on quality of life in patients with hepatocellular carcinoma after TACE

目的:观察康艾注射液对中晚期肝癌患者TACE(肝动脉化疗栓塞术)治疗后生活质量的影响。方法:选择BCLC B期或C期的原发性肝癌患者67例,随机分为两组,观察组给予康艾注射液联合TACE治疗,对照组给予单纯的TACE治疗。术后第7天查血常规、肝肾功能评估毒副反应,于术前及术后第10天采用欧洲癌症研究及治疗组织生活质量核心量表(EORTC QLQ-C30)评价患者生活质量的改变。结果:观察组白细胞减少、肝功能损害发生率小于对照组(P<0.05);观察组在降低症状领域评分,升高QLQ-30功能领域、总体健康状况领域评分方面显著优于对照组(P<0.05)。结论:康艾注射液可以减轻中晚期肝癌患者TACE治疗后的毒副反应,改善肝癌患者的症状,提高生活质量。

Objective：To observe the efficacy of Kang′ai-injection on quality of life in patients with hepatocellu-lar carcinoma（ HCC ）after TACE（ transarterial chemoembolization ）. Methods：All 67 patients with HCC in BCLC stage B or C were randomly divided into the control group and the observation group. The observation group received Kang′ai-injection combined with TACE. The control group received only TACE. Blood routine,liver function and re-nal function were tested at the 7th day after TACE to evaluate adverse reactions. Patients completed the European Or-ganization for Research and Treatment of Cancer（ EORTC）QLQ-C30 before TACE and at the 10th day after TACE to assess quality of life. Results：The occurrence rate of adverse reaction such as leucopenia and liver function damage were lower in the observation group than that in the control group（p〈0. 05）. The observation group were better than control group in reducing the scores of symptom domains and increasing the scores of functional domains and globe health domains（p〈0. 05）. Conclusion：Kang′ai-injection combined with TACE decrease adverse reactions and im-proves symptoms and quality of life of patients.