软组织骨化性纤维黏液样瘤临床病理观察

Ossifying fibromyxoid tumor of soft part: A clinicopathological observation

目的:探讨软组织骨化性纤维黏液样瘤(ossifying fibromyxoid tumor,OFMT)临床病理学特征、诊断及鉴别诊断。方法:结合文献对2例骨化性纤维黏液样瘤患者的临床表现、组织形态学特点、免疫组化、组织来源和预后进行探讨。结果:骨化性纤维黏液样瘤有纤维性包膜及不连续的骨壳,肿瘤实质呈大小不一的小叶状结构,细胞密度不均,瘤细胞间为多少不等的纤维黏液样基质。免疫组化肿瘤细胞表达Vim、GFAP、CD99、NSE。结论:软组织骨化性纤维黏液样瘤少见,易误诊,主要依据其典型的镜下形态并结合免疫组化做出诊断。免疫组化结果支持OFMT雪旺细胞起源。

Objective：To study the clinical and pathologic features,diagnosis and differential diagnosis of ossifying fibromyxoid tumor. Methods：The clinical manifestations,histopathological featrures,immunohistochemistry,histogene-sis and prognosis were analyzed in two cases of ossifying fibromyxoid tumor with review of the literatures. Results：Os-sifying fibromyxoid tumor was encapsulated with an incomplete of bone within the capsule in most cases. The tumor parenchyma consisted lobules of variable size and cellularity,with myxiod and/or fibrous stroma. Immunophenotypes showed that the tumor was positive to Vim,GFAP,CD99 and NSE. Conclusion：OFMT is rare and easily misdiag-nosed. Its diagnosis mainly bases on the characteristics of histopathology and immunohistochemistry. Immunohisto-chemical result supported a Schwann-cell origin.