STAT2与肿瘤

STAT2 and tumor

STAT2是信号转导和转录激活因子(signal transducers and activators of transcription,STAT)家族中的一员,它被激活后转入细胞核内与特异性DNA结合,影响基因转录,参与细胞的生长、分化、生存和凋亡。重要的是,目前研究表明,STAT2基因缺失或过表达对肿瘤发生发展有着重要影响,与肿瘤血管生成、肿瘤增殖及肿瘤凋亡密切相关,并且在肿瘤的干扰素治疗中扮演着重要角色。本文就STAT2与肿瘤研究进展做一综述。

Signal transducers and activators of transcription 2 （STAT2）is a member of transcription factors family,which can be activated by some surficial cytokines,then enter the nucleus,combine with specific DNA,lead to increased transcriptional initiation.Thus STAT2 participates in cell growth,differentiation,survival,apoptosis.More importantly,the present studies show that deletion or overexpression of STAT2 gene has a significant impact on tumor development and closely related with tumors angiogenesis,proliferation and apoptosis,it also plays an important role in the interferon treatment of tumor.This review summarizes the current research about the relationship between STAT2 and tumors.