110℃高热碘油加平阳霉素栓塞肝血管瘤中远期疗效分析

Mid-long term clinical effects of the 110℃ pingyangmycin-lipiodol chemoembolization for the treatment of liver hemangiomas

目的对比研究高热碘油与常温碘油加平阳霉素乳剂经动脉化疗栓塞肝血管瘤的中远期临床疗效。方法选取拟接受介入治疗的48例肝血管瘤患者,随机分为实验组与对照组,每组24例,实验组给予110℃高热碘油加平阳霉素乳剂超选择肝动脉化疗栓塞,对照组给予常温碘油加平阳霉素乳剂超选择肝动脉化疗栓塞。术后随访6个月~5年,观察两组病灶体积变化,观察临床疗效与并发症。结果术后6个月~1年、1~3年、3~5年时,实验组有效率分别为73.68%（28/38）、92.11%（35/38）、92.31%（24/26）,对照组分别为62.50%（20/32）、81.25%（26/32）、84.62%（22/26）,两组差异有统计学意义（P均〈0.05）,实验组长期随访26个瘤体,体积缩小比例分别为（65.96±25.24）%、（81.38±20.68）%、（90.12±19.59）%;对照组长期随访26个瘤体,体积缩小比例分别为（50.15±24.47）%、（67.69±26.02）%、（77.58±25.18）%,差异有统计学意义（P均〈0.05）。结论与常温碘油加平阳霉素乳剂相比,110℃高热碘油加平阳霉素化疗栓塞肝血管瘤疗效更加显著。

Objective To compare the mid-long term effects of 110℃ pingyangmycin-lipiodol chemoembolization and pingyangmycin-lipiodol chemoembolization at room temperature in the treatment for liver hemangiomas.Methods A total of 48 patients with liver hemangiomas preparing for interventional therapy were chosen.All patients were randomly divided into the experimental group（n=24）with 110℃ pingyangmycin-lipiodol intra-aryerial chemoembolization and the control group（n=24）with pingyangmycin-lipiodol intra-aryerial chemoembolization at room temperature.All the patients were followed-up 6months—5years after operation,and the changes of tumor volume and clinical symptoms were observed.Results The efficacy rates of the experimental group 6 months—1years,1—3years,3—5years after operation,was73.68%（28/38）,92.11%（35/38）,92.31%（24/26）,respectively,and 62.50%（20/32）,81.25%（26/32）,84.62%（22/26）respectively in control group,the differences between the two groups were statistically significant（all P〈0.05）,the decreased rates of 26 tumors in experimental group with long term follow-up was（65.96±25.24）%,（81.38±20.68）%,（90.12±19.59）%,respectively,and then,which was（50.15±24.47）%,（67.69±26.02）%,（77.58±25.18）%in control group,the differences were statistically significant（all P〈0.05）.Conclusion The curative effects of110℃ pingyangmycin-lipiodol chemoembolization for liver hemangiomas are better than that of pingyangmycin-lipiodol chemoembolization at room temperature.