乳腺癌新辅助化疗前后超声造影表现

CEUS performance of breast cancer before and after neoadjuvant chemotherapy

目的探讨乳腺癌新辅助化疗前后的超声造影表现。方法将接受乳腺癌新辅助化疗(NAC)的31例患者作为研究对象,以术前的穿刺病理和术后的手术病理为参照标准,比较化疗前后肿瘤的超声造影增强模式,并应用时间-强度曲线分析软件对参数进行分析。结果乳腺癌NAC前后,肿瘤的CEUS类型以不均匀增强为主[化疗前(18/31,58.06%),化疗后(21/31,67.74%)],化疗后无增强的肿瘤明显增多[(化疗前0,化疗后(5/31,16.13%)]。造影参数分析:化疗后的上升时间增加,峰值强度及曲线下面积降低,差异均有统计学意义(P均<0.05)。结论乳腺癌NAC前后,肿瘤的CEUS增强类型以不均匀增强为主,化疗后无增强的比例明显增高。化疗前后肿瘤CEUS的时间-强度曲线指标中,上升时间、峰值强度和曲线下面积是有价值的指标。

Objective To investigate the CEUS performance of breast cancer before and after neoadjuvant chemotherapy（NAC）.Methods A total of 31 patients receiving NAC were taken as research object.Pre-operative biopsy and post-operative surgical pathologies were taken as the reference standard.CEUS performance before and after NAC were compared,and the time-intensity curve of the tumor was analyzed.Results The inhomogeneous enhancement was typical in CEUS before and after NAC（58.06% [18/31]and 67.74% [21/31]）,without non-enhancement.While after NAC,the number of non-enhancement tumor significantly increasesd（5/31,16.13%）.As for the mass parameter,the rise time,peak intensity and area under the curve before and after the NAC had statistical significance（all P〈0.05）.Conclusion After the NAC,enhancement type of CEUS of breast cancer is mainly inhomogeneous and the rate of non-enhancement significantly increases.Gamma-variate analysis shows statistically significant differences in rise time,peak intensity and area under the curve before and after NAC.