枸橼酸咖啡因治疗早产儿原发性呼吸暂停疗效观察

Observation on effect of caffeine for treatment of premature infants

目的探讨咖啡因治疗早产儿原发性呼吸暂停的临床效果.方法：将69 例原发性呼吸暂停早产儿随机分成治疗组（35 例）、对照组（34 例）,2 组早产儿分别给予咖啡因和氨茶碱治疗,连用3～5 天,用药48 h 后评价疗效.观察用药48 h 内不良反应,用药前及用药1 周时查头颅B 超了解颅内出血情况.结果：治疗组显效率及总有效率分别为88.6%和94.3%,均高于对照组 （P〈0.05）.治疗组和对照组高血糖、心率增快、烦躁不安、喂养不耐受、颅内出血等不良反应发生率也低于对照组（P〈0.05）.结论：应用咖啡因治疗早产儿原发性呼吸暂停有效、合理,不良反应少,值得临床推广使用.

Objective To research the curative effect of caffeine for treatment of primary apnea in premature infants. Methods： A total of 69 premature infants with primaryapnea were randomly divided into group treatment group （35 infants）,control group （34 infants）, the premature infants in the two groups were treated with caffeine andAminophylline respectively for 3-5 days,then the curative effects were evaluated after 48 hours; the adverse reactions within 48 hours after treatment were observed; intracranialhemorrhage was detected by head ultrasonography before treatment and at one week after treatment. Results： The obvious effective rate and total effective rate in treatment group were88.6%and 94.3%,respectively,which were statistically significantly higher than those in groupcontrol group （P〈0.05）.The incidences of adverse reactions,such as hyperglycemia,increase of heart rate,dysphoria,feeding intolerance,and intracranial hemorrhage in treatment group were statistically significantly lower than those control group （P〈0.05）.Conclusion： caffeine was effective,reasonable,and had fewer adverse reactions for treatment of primary apnea in premature infants,and the method isworthy to be popularizedand applied in clinic.