VEGF-C与新生淋巴管在肺腺癌和鳞癌中的表达特点及临床预后意义评价

VEGF-C expression characteristics of lymphangiogenesis in lung adenocarcinoma and squamous cell carcinoma and clinical evaluation of prognostic significance

目的 探究VEGF-C（血管内皮生长因子）（vascular endothelial growth factor-C）和新生淋巴管在非小细胞肺癌中的表达特点以及相应的临床预后运用价值.方法： 选取2006 年3 月至2009 年6 月在我院胸外科进行手术治疗的肺腺癌和鳞癌的患者63 例,对其组织样本进行取样检查得以确诊,通过免疫组化技术检测患者体内的VEGF-C 表达量,电镜技术观察新生淋巴管状况,并对应相应的病理检查进行比较分析.结果： VEGF-C 在组织中的表达量与新生淋巴管的密度呈现正相关,同时在肺腺癌中,VEGF-C 与淋巴管的新生状况明显高于肺鳞癌患者（P〈0.05）,经过一年的随访显示VEGF-C 阳性患者的生存率明显低于阴性患者,因此VEGF-C 可以作为小细胞肺癌患者预后生存率的一个重要参考指标.结论： 在同等分期的肺腺癌患者的淋巴管新生情况较肺鳞癌患者严重,VEGF-C 是影响患者预后的重要因素.

ObjectiveExplore the VEGF-C （vascular endothelial growth factor） and lymphangiogenesis Expression tube in non-small cell lung cancer and clinical outcomesusing the corresponding value.Methods： Selected 63 patients from March 2006 to June 2009 in our hospital for surgical treatment of thoracic surgery lung adenocarcinoma andsquamous cell carcinoma, diagnosed sampling checks to their tissue samples by immunohistochemistry to detect VEGF patient -C expression levels observed by electron microscopylymphangiogenesis conditions and the corresponding pathology corresponding comparative analysis.Results： VEGF-C expression levels in tissue density lymphangiogenesis positivecorrelation, while in lung adenocarcinoma, newborn status VEGF-C and lymphatic vessels was significantly higher than in patients with squamous cell lung carcinoma （P 〈0.05）, aftera year follow-up showed survival VEGF-C positive patients was significantly lower than patients with negative, so VEGF-C can be used as small-cell lung cancer survival prognosis ofpatients with an important reference.Conclusion： LYMPHANGIOGENESIS case in patients with lung cancer compared with the same stage of lung squamous cell carcinoma inpatients with severe, VEGF-C is an important factor affecting the prognosis of patients.