384例婴幼儿迁延性及慢性腹泻病病因分析

Causes analysis of 384 infants with persistent or chronic diarrhea.

目的探讨安康地区婴幼儿迁延性、慢性腹泻病的病因及相关高危因素.方法：2006 年6 月～2012 年12 月期间住院的迁延性及慢性腹泻病患儿384 例临床资料进行回顾性分析.结果：384 例患儿非感染性因素占67.7%,其中锌缺乏71.5%,乳糖吸收不良56.9%,肝损害53.1%,免疫功能低下32.3%,轻度贫血例29.3%,中度营养不良2.3%,过敏因素1.04%;感染性因素所占的比例为32.3%,其中粪便培养阳性111 例,条件致病菌108 例.结论：安康地区迁延性及慢性腹泻病病因以非感染性因素为主,占67.7%,常多因素并存,其中锌缺乏、乳糖吸收不良居首位;感染性因素所占的比例为32.3%,粪便培养以条件致病菌为主;抗生素使用、锌缺乏、乳糖不耐受、免疫功能低下仍是迁延性及慢性腹泻病的常见原因.

sObjectiveTo analyze the etiology and risk factors of persistent or chronic diarrhea disease in infant of Ankang area.Methods：A total of 384 infant with persistentor chronic diarrhea were reviewed in pediatric gastroenterological wards during June 2006 to December 2012.Results：Infectious factors accounted for 32.3%, the stool culture waspositive in 111 cases, 108 cases of opportunistic pathogens .Noninfectious factors accounted for 67.7. Zinc deficiency in71.5%, lactose intolerance in56.9%, hepatic injury in53.1%,inmunnocompromise in32.3% , mild anemia in 29.3% cases, moderate malnutrition in 3%,allergic factors in1.04%.Conclude：Main causes of diarrhea disease were noninfective factors, accounted for 67.7%. Multiple factors often coexist zinc deficiency and lactose malabsorption were at the top infectious factors accounted for 32.3%, opportunisticpathogens were the main cause of stool culture; use of antibiotics, zinc deficiency , lactose intolerance, immunocompromised is still a common cause of persistent or chronic diarrheadisease.