老年高血压患者血压变异性与肾功能损伤的相关性分析

Correlation analysis of blood pressure variability and renal function injury in elderly hypertensive patients

目的探讨老年高血压患者血压变异性与肾功能损伤的相关性.方法： 90 例原发高血压患者进行24h 的动态血压检查,日间、夜间舒张压及收缩压的均值、变异值.采用eGFR 评估肾损伤的程度,并根据eGFR 的测定结果将患者分为研究组和对照组,对比两组患者的动态血压监测数据,考察血压变异性与eGFR 的相关性.结果：研究组患者24hDBP 显著高于对照组,24hSBPSD 显著高于对照组（P〈0.05）.日间SBPSD、日间DBPSD、24hSBPSD 与eGFR 呈明显的负相关.24 hDBP（β=-0.103,OR=0.901,P=0.011）及24 h SBPSD（β=-0.064,OR=0.937,P=0.042）均与eGFR 具有独立的相关性.结论：整体血压水平及血压变异性与高血压患者肾损伤程度受均具有密切的关系.

ObjectiveTo investigate the correlation between blood pressure variability and renal function injury in elderly hypertensive patients. Methods：24h ambulatoryblood pressure was carried out in 90 cases of primary hypertension to record the mean value and changes of SBP and DBP during daytime and night time. The eGFR was used toevaluate the degree of renal damage and divided into control group and study group by the results. The data was compared between two group to investigate the correlation betweenblood pressure variability and eGFR. Results：24hDBP and 24hSBPSD in study group were significantly higher than that in study group. There were independent associations between24 hDBP（β=-0.103,OR=0.901,P=0.011）, 24 h SBPSD（β=-0.064,OR=0.937,P=0.042） and eGFR. Conclusion：It Closely related to the renal function injury that blood pressureand blood pressure variability.