灵芝煎剂治疗急性百草枯中毒肺、肾保护作用的实验研究

目的探讨灵芝煎剂在急性百草枯中毒的治疗中对肺、肾所发挥的保护作用.方法：选择80 只健康SD 大鼠作为研究对象,分为观察组和对照组.为两组大鼠代谢检测之后.对照组生理盐水进行灌胃,观察组于百草枯染毒造模后2 小时使用质量系数100%灵芝煎剂4ml 进行灌胃,比较两组大鼠经灌胃之后肺、肾的各项生化,病理指标及大鼠的存活和活动情况.结果：比较两组大鼠经治疗后其体内轻脯氧酸、TGF-β 1 含量、肌酐以及尿素氮及生活检测结果,两者差异显著具有统计学意义（P〈0.05）;病理检验结果显示,对照组肺、肾组织无明显改变,观察组组织呈明显炎性细胞浸润现象.结论：急性百草枯中毒后动物体的肺、肾组织造成损害,而灵芝煎剂则其具有保护作用,有效的减轻实验动物体组织的损伤,降低死亡率,并呈量效关系.

objective： to study the ganoderma lucidum decoction in the treatment of acute paraquat poisoning of lung and kidney play a protective role. Methods： 80 healthy SDrats as the research object, is divided into observation group and control group. For metabolic detection after two groups of rats. Control group normal saline lavage, observation groupwithin 2 hours after the paraquat canister to build model using quality coefficient of 100% up to 4 ml ganoderma lucidum decoction lavage, compared two groups of rats after to fill thestomach, lung, kidney, the biochemical and pathological indicators and survival and activity in rats. Results： to compare the two groups of rats after treatment, the light pulp oxygenacid in the body, TGF - 1 content, creatinine and urea nitrogen and life test results, the significant difference statistically significant （P 〈 0.05）; Pathological examination, according tothe results of the control group no significant changes in lung, kidney tissues group organization obviously inflammatory cell infiltration phenomenon. Conclusion： acute paraquatpoisoning animals after lung, kidney damage, the ganoderma lucidum decoction is the protective, effectively reduce experimental animal body tissue damage, reduce mortality, andassumes the concentration-response relationship.