红景天注射液结合目标导向性治疗在外科高风险手术后的应用

The effect of rhodiola rosea injection application with Goal Directed Therapy of the high-risk postoperative.

目的观察红景天结合目标导向性治疗在外科高风险手术病人术后使用效果.方法：选取2011 年7 月至2013 年7 月入住我院重症监护室 （Intensive Care Unit,ICU）的普外科高风险手术患者120 例,将其随机分为红景天结合目标导向性治疗组（红景天组）、目标导向性治疗（goal directed therapy,GDT）组和对照组.红景天组在术后常规治疗的基础上,采用红景天注结合GDT 治疗;GDT 组在术后常规治疗的基础上,采用GDT 治疗;对照组则采用术后常规治疗.观察对比各组病例在中心静脉血氧饱和度（Central Venous Oxygen Saturation,ScvO2）、血乳酸（Blood Lactic Acid,BLA）的差异,并比较其术后并发症发生率. 结果：红景天治疗组在使用红景天3 天后其ScvO2 和BLA 与常规组间存在显著性差异（p〈0.01）;GDT 组与常规组间的ScvO2 和BLA 也存在显著性差异;红景天治疗组和GDT 组间无差异.术后并发症方面,红景天组和GDT 组均能降低术后并发症的发生率（p〈0.01）,红景天组在心血管系统的发生率在与GDT 组（P〈0.05）和对照组（P〈0.01）均存在差异.红景天组在降低术后心血管系统并发症上更具优势.结论：红景天结合目标导向性治疗作为外科高风险手术的术后处理具有很好的应用前景.可以有效改善机体的缺氧状况,降低术后并发症的发生率,且较传统GDT 治疗在术后的应用更具优势.

Objective Observe the effect of rhodiola rosea injection application with Goal Directed Therapy of the high-risk postoperative. Methods： From July 2011 to July2013, 120 cases of high-risk surgical patients admitted into surgical Intensive Care Unit（SICU） were enrolled and randomized into three groups. Rhodiola group： Rhodiola roseainjection application with Goal Directed Therapy. After operation, based on both the conventional therapy and GDP, we use the rhodiola rosea injection 20ml everyday in the first 3days.Goal directed therapy group： After operation, based on the conventional therapy we use the GDP. Control group： After operation, based on the conventional therapy. ScvO2, lacticacid, SaO2 was measured, and the incidence of postoperative complications were observed and compared. Results：After 3days of using rhodiola rosea injection, compared with controlgroup, there has significantly difference on ScvO2 and lactic acid either in rhodiola group or in GDT group, while there had no difference between rhodiola group and GDT group.Rhodiola group had more advantages in the reduction of postoperative complications of cardiovascular system. Conclusion：As postoperative treatment of high-risk surgery rhodiolarosea injection application with Goal Directed Therapy has good application prospect. It can improving hypoxia condition, and reducing the incidence of postoperative complications.It’s postoperative use may have more advantages than GDT.