水飞蓟宾葡甲胺片对结核药引起的药物性肝损伤治疗疗效观察

Clinical Observation of Shuifeijibingpujiaan on Treating to Anti-tuberculosis Drug IInduced Liver Injury

目的观察水飞蓟宾葡甲胺片对结核药引起的药物性肝损伤治疗疗效.方法：将92 例结核药引起的药物性肝损伤随机分为治疗组和对照组,治疗组结核药（H＋S＋R＋Z）＋水飞蓟宾片,对照组结核药（H＋S＋R＋Z）＋护肝片（葵花牌）进行治疗,疗程均为9 个月.观察比较两组患者肝功能的变化.结果：治疗组的肝功能复常率明显高于对照组（P〈0.05）.结论：水飞蓟宾葡甲胺片治疗结核药引起的药物性肝炎疗效确切.

ObjectiveTo observe the therapellsic effect of shuifeijibingpujiaan decoction on anti-tuberculosis drug induced liver injury （DILI）.Methods：Ninty two patientswere randanly devided into two groups ,in treatment group （n=50）,tuberculosis drug（H＋S＋R＋Z） combined with shuifeijibingpujiaanpian.In control group（n=40）, tuberculosisdrug（H＋S＋R＋Z） combined with huganpian（kuihuapai）, The patients were followed up for 9-12 months. Results：The recovery rate of transaminase of treatment group was higher thanthat of control group（p〈0.05）. Conclusion：shuifeijibingjiapuanpian has definite therapelltic effect tuberculosis drug induced liver injury