TGF-β1/Smads信号通路在高血压心肌纤维化中的调控机制研究

高血压作为心脏病的高危因素,有一半的心血管疾病都是因为高血压而造成的,心肌纤维化（MF）是高血压引起心脏损害的重要病理特征,而高血压MF是现阶段致残率非常高的一种疾病,MF 与心脏间质的重构是这种病致残与预后不良的重要因素,其发病机制比较复杂,而转化生长因子（TGF-β1）/Smads 的信号通路和高血压MF 有密切的关系,从该通路入手,找出防治高血压MF 的方法对有效治疗高血压MF 具有重要意义.

hypertension as risk factors for heart disease, half of the cardiovascular diseases are caused because of hypertension, myocardial fibrosis （MF） is an importantpathological feature of cardiac damage caused by hypertension, but hypertension MF is currently disabled rate of a disease is very high, MF and reconstruction of cardiac interstitial areimportant factors this disease disability and poor prognosis, its pathogenesis is more complex, and transforming growth factor - （TGF- beta 1） there is a close relationship between the/Smads signal transduction pathway and hypertension MF, starting from the path and method to find out the prevention and treatment of hypertension in MF is of great significance tothe effective treatment of hypertension MF.