小生六汤加减干预亚健康临床研究

Clinical Observation of Modified Xiaoshengliu Decoction for Intervention of Sub-health Population

【目的】观察具有益气养阴、疏肝解郁、补益脾肾等功效的小生六汤加减对亚健康病例的干预效果。【方法】以南方医科大学南方医院中医科罗仁教授进行亚健康干预的就诊者为研究对象,由罗仁教授根据四诊资料,应用南方医科大学亚健康研究项目制定的《亚健康调查表》进行量化评估,筛选出亚健康研究病例,给予小生六汤(由柴胡、黄芩、法半夏、党参、熟地黄、山药、山茱萸、牡丹皮、麦冬、五味子、炙甘草等药物组成)加减干预方案对研究病例进行亚健康干预,并应用《亚健康状态症状观察表》对治疗前后症状跟踪随访,并评价其疗效。【结果】(1)小生六汤干预后首次随访的总有效率为92.03%,末次随访的总有效率为100.00%,末次随访与首次随访结果比较,差异有统计学意义(P<0.01)。(2)对干预前、首次随访和末次随访的症状积分进行单因素方差分析,差异有统计学意义(P<0.01)。首次随访和末次随访的症状积分均低于干预前(P<0.01),末次随访的症状积分低于首次随访(P<0.01)。【结论】小生六汤加减用于临床气阴两虚型亚健康人群的干预治疗,具有良好的临床疗效。

Objective To observe the intervention of sub-health population with modified Xiaoshengliu Decoction, a Chinese herbal recipe with the actions of strengthening Qi and nourishing yin, soothing liver and relieving stagnation, tonifying liver and kidney. Methods The clients of professor LUO Ren from Dept. of Traditional Chinese Medicine, Nanfang Hospital Affiliated to Southern Medical University, were chosen as the studying objects. Sub-health outpatient cases were defined according to the data of four diagnostic methods together with Sub-health Questionnaire developed by the sub-health program of Southern Medical University, and then were given modified Xiaoshengliu Decoction （mainly composed of Radix Bupleuri, Radix Scutellariae, Rhizoma Pinelliae Preparata, Radix Codonopsis, Radix Rehmanniae Preparata, Rhizoma Dioscoreae, Fructus Corni, Cortex Moutan, Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Glycyrrhizae Preparata, etc.） for intervention. The symptoms of the subjects were followed up before and after treatment for the evaluation of therapeutic effect with Sub-health State Symptom Checklist. Results （1） The results showed that the total effective rate was 92.03%at first follow -up, and was 100% at the last follow-up, the difference being significant between the two periods of follow-up （P〈0.01） . （2） The results of single-factor variance analysis showed that the differences of symptoms scores before treatment, at the first and the last follow-up were statistically significant （P〈0.01） . The symptoms scores before treatment, at the first follow-up and at the last follow-up were in decreasing sequence （P〈0.01） . Conclusion Modified Xiaoshengliu Decoction shows certain effect on the intervention of sub-health population with the syndrome of Qi-yin deficiency .