中药离子导入敷贴防治小儿反复呼吸道感染方案比较

Clinical Efficacy Analysis of Herbal Ion Application and Penetration Therapy for Prevention and Treatment of Recurrent Respiratory Tract Infection in Children

【目的】比较夏季三伏、冬夏伏九2种中药离子导入敷贴方案防治小儿反复呼吸道感染(recurrent respiratory tract infection,RRTI)的临床疗效。【方法】采用多中心、随机对照、重复测量、单盲设计,临床收集240例反复呼吸道感染患儿,随机分为三伏组和伏九组各120例,借助离子导入仪,进行中药穴位敷贴,治疗1年,再随访1年,观察2组治疗前后呼吸道感染的发病次数、发作期病程、中医症候,并分时间点检测唾液分泌型免疫球蛋白A(sIgA)。【结果】(1)伏九组临床疗效优于三伏组,2组比较差异有统计学意义(P<0.05)。(2)2组均可减少发病次数,缩短发作期病程,改善中医症候(P<0.05),其中伏九组较三伏组作用更显著(P<0.05)。(3)伏九组不同时间点sIgA呈持续上升趋势,三伏组不同时间点sIgA呈轻度下降趋势(P<0.05)。【结论】中药离子导入敷贴防治小儿反复呼吸道感染,冬夏伏九方案优于夏季三伏方案,值得临床继续探讨。

Objective To compare the clinical efficacy of herbal ion application and penetration therapy applied in the dog days, or in both of the dog days and coldest days for the treatment of recurrent respiratory tract infection （RRTI） in children. Methods This intervention was designed as a multi-center, randomized, single-blind, repeated-measurement design. A total of 240 RRTI children were randomly divided into Sanfu group （N=120, herbal ion application and penetration therapy applied in the dog days） and Fujiu group （N=120, herbal ion application and penetration therapy applied in both of the dog days and coldest days）. Each group was treated for one year and then was followed up for one year. Before and after the treatment, we observed the frequency of respiratory tract infection, the period of onset, signs and symptoms of traditional Chinese medicine （TCM）, and detected the salivary secretory immunoglobulin A （sIgA） at different time points. Results （1） The therapeutic effect of Fujiu group was better than that of Sanfu group, and the difference was significant （P〈0.05）. （2） The frequency of respiratory tract infection was reduced, the period of onset was shortened, and TCM signs and symptoms were improved in both groups, and the effect of Fujiu group was superior to that of Sanfu group （P〈0.05）. （3） Salivary sIgA showed a continuous upward trend in Fujiu group while a mild downward trend in Sanfu group at different time points （P〈0.05）. Conclusion Herbal ion application and penetration therapy applied in both of the dog days and coldest days shows better effect for the treatment of children RRTI than that applied only in the dog days.