瑞舒伐他汀钙对急性脑梗死患者血脂和血清超敏C反应蛋白的影响

Effect of Rosuvastatin calcium on serum lipoprotein and high sensitivity C-reactive protein in patients with acute cerebral infarction

目的比较瑞舒伐他汀钙和辛伐他汀对急性脑梗死患者血脂的疗效,并对两组患者高敏C-反应蛋白(hs-CRP)水平对比分析。方法选取120例脑梗死合并高脂血症的患者,随机分为观察组和对照组各60例。分别予以瑞舒伐他汀钙、辛伐他汀治疗,用药4周后检测血清脂蛋白、hs-CRP水平。结果观察组较对照组血清低密度脂蛋白、hs-CRP显著降低(P<0.05)。结论瑞舒伐他汀钙可降低急性脑梗死患者的血脂及hs-CRP水平,对急性脑梗死具有较好的疗效。

Objective To investigate the effect of Rosuvastatin calcium on serum lipoprotein and high sensitiv‐ity C‐reactive protein （hs‐CRP） in patients with acute cerebral infarction. Methods A total of 120 patients with acute cerebral infarction combined with hyperlipidemia were enrolled and randomly divided into observation group （60 ca‐ses） and control group （60 cases）, respectively treated with Rosuvastatin and Simvastatin. After four weeks of treat‐ment, the levels of serum lipoprotein and hs‐CRP were determined. Results The levels of low density lipoprotein and hs‐CRP in observation group were lower than control group （P〈0. 05）. Conclusion Rosuvastatin might be efficient to reduce the levels of serum lipoprotein and hs‐CRP in patients with acute cerebral infarction.