摘要
目的:探讨应用注射用盐酸川芎嗪治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效。方法:选取2012年1月-2014年1月本院收治的AECOPD患者120例,按随机数字表法分为治疗组和对照组各60例,对照组为常规治疗组,治疗组在对照组基础上加用注射用盐酸川芎嗪治疗。比较两组的临床疗效、动脉血气分析、肺功能变化和用药安全性。结果:治疗组治疗总有效57例,明显大于对照组的44例(P<0.05);且治疗组治疗后血气分析指标PaO2、pH分别为(80.8±12.6)mm Hg、(7.40±0.02),均明显大于对照组(P<0.05),PaCO2为(43.9±6.4)mm Hg,明显小于对照组(P<0.05);治疗组治疗后肺功能指标FVC、FEV1以及FEV1%分别为(2.20±0.08)L、(1.86±0.33)L、(66.7±13.4)%,与治疗前比较差异均有统计学意义(P<0.05),与对照组治疗后比较差异无统计学意义(P>0.05)。两组治疗期间均无明显不良事件发生。结论:注射用盐酸川芎嗪在AECOPD的治疗中的应用可明显提高疗效,改善患者临床症状,安全性高,为中西医结合治疗提供了更广泛途径。
Objective:To investigate the clinical curative effect of Ligustrazine Hydrochloride Injection in treatment of chronic obstructive pulmonary disease with acute exacerbation(AECOPD).Method:120 cases of AECOPD were selected in our hospital from January 2012 to January 2014,they were randomly divided into the treatment group (n=60)and the control group(n=60),the control group received conventional treatment,the treatment group in the control group based on the use of Ligustrazine Hydrochloride Injection treatment. The efficacy,arterial blood gas analysis,pulmonary function and medication safety of two groups were compared.Result:The total effective treatment of the treatment group were 57 cases,were significantly higher than the control group for 44 cases(P〈0.05);and after treatment,blood gas analysis indexes of PaO2,pH were(80.8±12.6)mm Hg,(7.40 ± 0.02),were significantly larger than that of the control group(P〈0.05),PaCO2(43.9±6.4)mm Hg,significantly less than the control group(P〈0.05);after treatment,lung function index FVC,FEV1 and FEV1%were(2.20±0.08)L,(1.86±0.33)L,(66.7±13.4)%, compared with those before treatment had significant difference(P〈0.05),no significant difference compared with the control group after treatment(P〉0.05). The two groups had no significant adverse events.Conclusion:the application of Ligustrazine Hydrochloride Injection in the treatment of AECOPD can significantly improve the curative effect,improve the clinical symptoms of patients,high safety,provides a broader way to combine traditional Chinese and Western medicine treatment.
出处
《中国医学创新》
CAS
2014年第30期17-19,共3页
Medical Innovation of China
基金
江西省卫生厅中医药科研基金课题(2013B028)
关键词
慢性阻塞性肺疾病
急性加重期
注射用盐酸川芎嗪
Chronic obstructive pulmonary disease
Acute exacerbation
Ligustrazine injection