摘要
目的：探讨儿童肥胖与血清25羟维生素D[25-（OH）D]及胰岛素抵抗的关系。方法：选取7~14岁肥胖儿童60例及正常体重儿童60例，抽血检测空腹血清25-（OH）D、血糖及胰岛素水平，采用胰岛素抵抗指数（HOMA-IR）评估胰岛素抵抗水平。比较两组血清25-（OH）D及胰岛素抵抗水平的差异。结果：肥胖儿童组血清25-（OH）D显著低于正常体重儿童组（P〈0.01）；肥胖儿童组HOMA-IR高于正常体重儿童组，差异有统计学意义（P〈0.01）；25-（OH）D与HOMA-IR呈负相关（r=-0.596，P〈0.01）。结论：肥胖儿童血清25-（OH）D低于正常儿童，且胰岛素抵抗水平高于正常体重儿童，对肥胖儿童监测25-（OH）D并适当补充维生素D，有利于改善胰岛素抵抗，减轻体重。
Objective：To investigate the relationship between childhood obesity and serum 25-（OH）D concentration and insulin resistance.Method：60 obese children aged 7 to 14 and 60 cases of normal weight children were selected. A fasting blood test was taken on serum 25-（OH）D concentrations,blood glucose and insulin. HOMA-IR was used to assess the level of insulin resistance. Tthe difference of serum 25-（OH）D concentration and insulin resistance was compared in the two groups.Result：The serum 25-（OH）D concentration of obese children was lower than that of normal children（P〈0.01）. HOMA-IR of obese children was higher than that of normal children. The difference was statistically significant（P〈0.01）. 25-（OH）D was negatively correlated with HOMA-IR（r=0.596,P〈0.01）. Conclusion：The serum 25-（OH）D concentration of obese children is lower than that of normal children. The level of insulin resistance of obese children is higher than that of normal weight children. Monitoring serum 25-（OH）D concentration in obese children and supply them with vitamin D is conductive to the improvement of insulin resistance and weight reduction.
出处
《中国医学创新》
CAS
2014年第30期110-112,共3页
Medical Innovation of China
基金
江西省卫生厅科技计划项目(20143228)
