氟西汀联合阿普唑仑治疗脑卒中后抑郁临床疗效

Clinical Efficacy of Fluoxetine Combined with Alprazolam on Post-stroke Depression

目的:观察氟西汀联合阿普唑仑治疗脑卒中后抑郁的临床疗效。方法:将2012年1月-2013年10月到本院精神科门诊就诊的脑卒中后抑郁患者按就诊顺序随机分为治疗组和对照组,每组40例。治疗组给予氟西汀联合阿普唑仑治疗,对照组给予黛力新联合多塞平治疗,疗程均为4周,随访3个月,从HAMD抑郁评估和临床神经功能缺损评分(MESSS)进行疗效评定。结果:治疗后,两组的HAMD抑郁总分与治疗前比较差异均有统计学意义(P<0.05),且治疗组更为明显;治疗后,两组的MESSS评分较治疗前均显著下降(P<0.01);两组总有效率、不良反应比较差异均无统计学意义(P>0.05)。结论:氟西汀联合阿普唑仑治疗脑卒中后抑郁疗效显著,副作用小,值得临床推广应用。

Objective：To observe the clinical efficacy of Fluoxetine combined with Alprazolam on post-stroke depression.Method：80 patients with depression after stroke from January 2012 to October 2013 in our hospital psychiatric outpatient were randomly divided into two groups,the treatment group and the control group,40 patients in each group. The treatment group was given Fluoxetine combined with Alprazolam to treatment,and the control group was given Deanxit combined with Doxepin to treatment. The efficacy was evaluated by the HAMD and MESSS score.Result：After treatment, HAMD depression scores of two groups were statistically significant differences which compared with before treatment, and the treatment group was more obvious（P〈0.05）;after treatment,MESSS score of two groups compared with before treatment were significantly decreased（P〈0.01）. The total effective rate,adverse reaction between the two groups had no statistical significance（P〉0.05）.Conclusion：The clinical efficacy of Fluoxetine combined with Alprazolam on post-stroke depression is very significant,and the side effect is seldomly,it is one method which is worth to popularize.