综合加权评分法优选姜半夏炮制工艺

Optimization of Processing Technology for Pinelliae Rhizoma Preparatatum Cum Zingibere et Alumine by Synthetic Weight Mark Method

目的:优选姜半夏最佳炮制工艺。方法:选择生姜用量、白矾用量、炮制时间3个因素,以姜半夏中有效成分总有机酸、炮制辅料生姜中6-姜醇的含量以及白矾残留量为考察指标,采用L9(34)正交试验设计,以多指标综合加权评分方法优选姜半夏炮制工艺,并与《中国药典》方法(生姜25 g,白矾12.5 g)比较及进行验证试验。结果:优选出姜半夏炮制工艺为每100 g净半夏加生姜25 g、白矾8 g,共炮制4 h;所得样品3次验证试验结果相似。结论:优选的炮制工艺与药典法比较确定了炮制时间,减少了白矾用量,既使姜半夏有效组分保持较高的含量,同时又降低了白矾残留量。

OBJECTIVE： To optimize the processing technology of pinelliae rhizoma preparatatum cum zingibere et alumine. METHODS： The processing technology of pinelliae rhizoma preparatatum cum zingibere et alumine was optimized by L9 （34） orthogonal test and multiple index synthetic weight mark method with the amount of Zingiber officinale and alum, processing time as factors, using the content of effective component total organic acid in pinelliae rhizoma preparatatum cure zingibere et alumine, the content of 6zingiberol in processed Z. officinale and the content of alum as index. It was compared with the method stated in Chi nese Pharmacopeia （Z. officinale 25 g, alum 12.5 g）, and the validation test was performed. RESULTS： The optimized processing technology was as follows： Pinellia ternate 100 g, Z. officinale 25 g, alum 8 g, processing for 4 h. The results of 3 validation tests were similar. CONCLUSIONS： Compared with the method stated in Chinese Pharmacopeia, the optimized processing technology confirms the processing time and reduces the amount of alum; not only maintains the high content of effective component of pi nelliae rhizoma preparatatum cum zingibere et alumine, but also reduces the amount of residual alum.