骨桥蛋白在卵巢癌中的表达及其与不同临床病理特征关系的Meta分析

Osteopontin Expression and Its Relation to Clinicopathologic Characteristics of Ovarian Cancer:A Meta-Analysis

目的:评价有关骨桥蛋白(OPN)在卵巢癌组织中表达的情况及与卵巢癌不同临床病理特征的关系。方法:系统检索NCBI PubMed、EMBASE、维普、万方数据库中截止2013年11月符合纳入标准的国内外公开发表的有关OPN在卵巢癌组织中表达的文献7篇,通过固定效应模型综合分析合并效应量,采用RevMan 5.1统计软件进行分析。结果:Meta分析显示,OPN在卵巢癌组和正常卵巢组表达差异有统计学意义[OR=20.24,95%CI(9.66,42.43),P<0.000 01]。OPN在卵巢癌组和良性卵巢组表达差异有统计学意义[OR=16.58,95%CI(9.60,28.64),P<0.000 01]。OPN在卵巢癌高分化组和中低分化组表达的差异有统计学意义[OR=0.16,95%CI(0.08,0.32),P<0.000 01]。OPN在卵巢癌临床Ⅰ-Ⅱ期组和临床Ⅲ-Ⅳ期组表达的差异有统计学意义[OR=0.16,95%CI(0.09,0.29),P<0.000 01]。OPN在卵巢癌淋巴结转移组和淋巴结未转移组表达的差异有统计学意义[OR=4.20,95%CI(2.24,7.88),P<0.000 01]。结论:OPN高表达与卵巢癌及其不同临床病理特征有显著相关性。但受纳入文献质量影响,还需进一步用国内外高质量的研究来证实。

Objective：To investigate the expression of OPN in human ovarian cancer and explore their relationship between the OPN expression and the clinicopathologic characteristics of ovarian cancer.Methods：Literature search was performed from the NCBI PubMed,EMBASE,VIP,Wangfang Database,and 7articles up to November 2013 were included about expression of OPN in patients with ovarian cancer.Results were combined with fixed effects models.RevMan 5.1software was applied to process data.Results：As for the positive rate of OPN expression,significant differences were tested between ovarian cancer vs.normal ovarian tissues,ovarian cancer vs.benign ovarian tissues,clinical stagesⅠ-Ⅱvs.clinical stagesⅢ-Ⅳ,and lymph node metastasis vs.non-lymph node metastasis respectively with OR（95%CI）at 20.24（9.66,42.43）,16.58（9.60,28.64）,0.16（0.08,0.32）,0.16,（0.09,0.29）and 4.20,（2.24,7.88）respectively.Conclusion：According to the domestic evidence,higher OPN expression might be associated with ovarian cancer.However,higher quality case-control studies are expected for further study.