细胞外基质的硬度与细胞生物学功能的研究进展

Research Progress of Biological Function and Rigidity of Extracellular Matrix

细胞外基质是细胞赖以生存的环境,细胞外基质中物质和代谢的不平衡导致细胞外基质硬度的变化,从而能够影响细胞的一系列生物学功能。本文阐述了近期关于细胞外基质的改变与力学相关性的研究,以及其对细胞的迁移、细胞核形态的改变、细胞分化、基因转移、细胞的信号转导方面的影响。

Cell survival environment is extracellular matrix,and Unbalanced metabolism of it could have effect on the biological function.Several recent reports have shown that cells modulate themselves in respond to their surrounding environment,including mechanical correlation,migration,modulation of nuclear shape,cell differentiation,gene transfer,modulation of signal transduction.