非糖尿病人群糖化血红蛋白水平对冠状动脉狭窄程度的预测价值

Value of Predicting Extent of Coronary Artery Stenosis by Glycosylated Hemoglobin Level of Patient without Diabetes

目的：探讨非糖尿病人群糖化血红蛋白水平与冠状动脉狭窄程度的关系。方法：收集非糖尿病患者426例,分为4.0%-5.0%（Ⅰ组）、5.1%-5.9%（Ⅱ组）、6.0%-6.4%（Ⅲ组）三组。另选同期糖尿病患者95例作对照。比较四组一般资料及冠状动脉狭窄程度情况。结果：三组非糖尿病患者FPG水平、伴高血脂患者的比例差异明显。Ⅰ、Ⅱ组冠状动脉以轻度狭窄为主,Ⅲ组虽然轻度狭窄比例较中、重度狭窄高,但重度狭窄的比例较Ⅰ、Ⅱ组明显增加;而对照组则以重度狭窄为主（P〈0.05）。结论：在非糖尿病患者中,动态监测HbA1c水平不仅有利于发现隐性糖尿病,还对冠状动脉的狭窄程度及病变范围进行预测,当发现HbA1c水平较正常轻度升高时,及时进行合理干预,这对预防冠心病的发生及进展有着重要意义。

Objective ：To investigate the relationship between glycated hemoglobin level of patient without diabetes and degree of coronary artery stenosis .Methods ：426 non diabetic patients were collected ,they were divided into 4.0% -5.0% （groupⅠ） ,5 .1% -5 .9% （group Ⅱ ） ,6.0% -6 .4% （group Ⅲ ） .95 diabetic patients were selected as control . The average data and coronary stenosis degree among four groups were compared .Results：The FPG levels and ratio with high cholesterol in three groups where patients were without diabetes had obvious difference .There were most mild stenosis of coronary artery in Ⅰ ,Ⅱ group ,in Ⅲ group although mild ,stenosis ,were higher than severe stenosis , but the proportion of severe stenosis were significantly higher than that of Ⅰ ,Ⅱ group;while in control group the severe stenosis were most（P〉0 .05）.Conclusion：In patients without diabetes ,monitoring the HbA1c not only helps to find latent diabetes ,but also predict stenosis degree of coronary artery and extent of disease ,when the HbA1c levels were slightly higher than normal ,timely and properly intervention is carried out ,it is important to prevent development and progression of coronary heart disease .