血清E选择素、sVCM-1在糖调节受损患者中的水平分析

Analysis Serum Levels of E-selection and Soluble Vascular Cell Adhesion Molecule-1 in Patients with Impaired Glucose Regulation

目的:探讨E选择素(E-selectin)、可溶性血管细胞黏附分子-1(sVCM-1)在糖调节受损(IGR)患者血清中的水平。方法:根据空腹血糖(FPG)及2h血糖(2hPG)水平,分为正常糖耐量组(NGT组,35例),空腹血糖受损组(IFG组,25例)、糖耐量减低组(IGT组,23例)、空腹血糖受损合并糖耐量减低组(IFG+IGT组,26例)和2型糖尿病组(DM组,18例)。均为体检中新发现者。结果:血清中E-selectin水平在各组中比较显示,除IFG组与IGT组两组水平无明显差异外(P>0.05),其他各组血清中E-selectin水平比较差异均具有统计学意义(P<0.01);而血清中sVCM-1水平在各组中比较差异均具有统计学意义(P<0.01)。结论:动态观察血清中E-selectin、sVCM-1的水平,可以早期采取相应的干预措施,防止和延缓血管内皮的损伤和DM的发生发展,预防心血管事件的发生。

Objective ：To investigate the serum levels of E‐selection and soluble vascular cell adhesion molecule‐1 in pa‐tients with impaired glucose regulation .Methods ：According to the Fasting serum glucose（FPG） and 2‐hour serum glu‐cose（2hPG ） levels ,divided into the normal glucose tolerance group （NGT group ,35 cases） ,impaired fasting glucose group（IFG group ,25 cases） ,impaired glucose tolerance group（IGT group ,23 cases） ,impaired fasting glucose with im‐paired glucose tolerance group（IFG ＋ IGT group ,26 cases）and Diabetes mellitus Type‐2 group（DM group ,18 cases） , were found in physical examination above all .Results ：The level of E‐selectin in serum compared in each group ,but no significant difference in IFG group and IGT group two group level （P 〉 0 .05） ,the level of E‐selectin in serum com‐pared with other group differences were statistically significant （P 〈 0 .01） ;while the sVCM‐1 level in serum in each group compared the difference had statistical significance （P 〈0 .01） .Conclusion ：Dynamic observation of serum E‐se‐lectin ,sVCM‐1 levels ,early intervention measures ,to prevent and delay the occurrence and development of vascular endothelial injury and DM ,prevent the occurrence of cardiovascular events .