纳洛酮联合神经节苷脂治疗新生儿缺氧缺血性脑病的临床疗效观察

Effect of Naloxone Combined with Ganglioside on Neonatal Hypoxic-ischemic Encephalopathy

目的探讨纳洛酮联合神经节苷脂治疗新生儿缺氧缺血性脑病(HIE)的临床疗效。方法选取2013年8月—2014年1月我院收治的HIE患儿62例,将其随机分为观察组和对照组,各31例。对照组患儿给予常规治疗,观察组患儿在常规治疗基础上给予纳洛酮联合神经节苷脂进行治疗。治疗10 d后观察两组临床疗效,记录治疗前后两组患儿神经行为测定(NBNA)评分。结果观察组患儿优14例,良15例,差2例;对照组患儿优9例,良12例,差10例。观察组患儿临床疗效优于对照组(P<0.05)。治疗前两组患儿NBNA评分比较,差异无统计学意义(P>0.05);治疗后观察组患儿NBNA评分高于对照组(P<0.05)。结论纳洛酮联合神经节苷脂治疗新生儿HIE临床疗效显著,且能在较短时间内提高患儿NBNA评分。

Objective To investigate the effect of neonatal combined with ganglioside on neonatal hypoxic- ischemic encephalopathy（ HIE）. Methods From August 2013 to January 2014,62 infants with neonatal HIE in our hospital were chosen,and then they were randomly divided into observation group and control group,each of 31 cases. Control group given conventional therapy,while observation group given naloxone combined with ganglioside. Curative effect after 10 days of treatment between the two groups was compared,and NBNA score before and after treatment were recorded. Results In the observation group,14 cases got excellent effect,15 cases got good,2 cases got poor; while in the control group,9 cases got excellent effect,12 cases got good,10 cases got poor. Curative effect of observation group was better than that of control group（ P〈0. 05）. There was no significant differences of NBNA score between the two groups before treatment,but NBNA score of observation group was higher than that of the control group after treatment（ P〈0. 05）. Conclusion Naloxone combined with ganglioside has good effect on neonatal HIE,which can improve their NBNA score in a relatively short period.