土鳖虫冻干粉对高脂饮食肉兔血脂的影响

Effect of eupolyphaga freeze-dried powder on the blood lipid of rabbit fed with high-fat diet

为研究土鳖虫冻干粉对高脂饮食肉兔血脂生理指标的影响,选择健康的150只肉兔随机分成5组,即空白组、高脂组和三个不同剂量组(0.4、0.2、0.1 g·kg-1土鳖虫冻干粉),每20 d每组随机抽取5只肉兔心脏静脉血,分离血清,用于测量血清中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)含量。结果表明,高脂组血脂水平显著高于空白组(P<0.05);高剂量组和低剂量组TC、TG显著高于空白组(P<0.05),与高脂组差异不显著(P>0.05);高、中、低剂量组LDL-C均显著高于空白组和高脂组(P<0.05);中剂量组TC、TG、LDL-C水平显著低于高脂组(P<0.05),与空白组差异不显著(P>0.05)。结果显示,土鳖虫冻干粉可抑制高脂饮食肉兔血脂水平升高,具有调节血脂作用。中剂量组(0.2 g·kg-1)为最佳剂量。

To study the effects of eupolyphaga freeze-dried powder on blood lipids physiological indi-ces in rabbits with high-fat diet. Total 150 rabbits were selected and randomly divided into five groups, con-trol group, high-fat group and three different dosage eupolyphaga groups（0.4, 0.2, 0.1 g·kg^-1 eupolyphaga freeze-dried powder）. Every 20 d, each group of randomly selected five rabbits to draw cardiac venous blood, separation of serum, used to measure the serum＇s total cholesterol （TC）, triglyceride （TG）, high-density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C） levels. The results showed that the blood lipid of high-fat group was abnormal, compared with control group, the levels were significantly in-creased（P〈0.05）;Compared with control group, the levels of TC, TG in high group and low group were signif-icantly increased（P〈0.05）, no significant differences（P〉0.05） were observed between high group, low group and high-fat group. Compared with control group and high-fat group, the levels of LDL-C in high group, medi-um group and low group were significantly increased（P〈0.05）; Compared with high-fat group, TC, TG, LDL-C of medium group were significantly reduced（P〈0.05）. No significant differences（P〉0.05） were ob-served between the medium group and control group. Results showed that the Eupolyphaga Freeze-dried powder can inhibit the rise of the blood lipid of rabbit fed with high-fat diet and regulate blood lipid. The re-sults showed that eupolyphaga freeze-dried powder could inhibit the rise of the blood lipid of rabbit fed with high-fat diet, could regulate blood lipid. Medium group （0.2 g·kg^-1） was the best dosage.