奥美拉唑、泮托拉唑与兰索拉唑预防应激性溃疡疗效比较

Study on Effect of Omeprazole,Pantoprazole and Lansoprazole in Preventing Stress Ulcer

目的观察并比较奥美拉唑、泮托拉唑与兰索拉唑用于预防应激性溃疡的疗效。方法选取2012年1月至2013年12月住院治疗的120例具有消化性溃疡高危因素的患者,并将患者随机分入A,B,C 3组,分别使用奥美拉唑、泮托拉唑和兰索拉唑预防应激性溃疡。观察各组患者治疗后胃液p H、上消化道出血发生率及不良反应,以评价3种药物的疗效。结果 3组患者用药7 d后胃液p H均显著上升,较治疗前差异有统计学意义(F=41.29,P<0.001),其中C组患者在治疗3 d后胃液p H明显高于另外两组(F=7.14,P<0.05);3组患者中应激性溃疡发生率C组最低(7.50%),B组最高(17.50%),但差异无统计学意义(Z=1.83,P>0.05);各组腹泻、肌痛、视觉异常和皮炎等不良反应发生率差异无统计学意义(P>0.05)。结论奥美拉唑、泮托拉唑与雷贝拉唑均可有效预防应激性溃疡,且疗效确切,安全可靠。

Objective To investigate the clinical effect of omeprazole, pantoprazole and lansoprazole in preventing stress ulcer（ SU）.Methods 120 cases of SU high risk factors in our hospital from Jan. 2012 to Dec. 2013 were selected as the research subjects and randomized assigned into the group A,B and C. The group A,B and C were respectively given omeprazole,pantoprazole and pansoprazole for preventing SU. The p H value of gastric juice,occurrence rate of upper digestive tract hemorrhage and adverse reactions in each group were observed and the clinical effect of the 3 kinds of drug was evaluated. Results The p H value of gastric juice after 7 d medication showed a significant rise in all groups, the difference between before and after treatment had statistical significance（ F =41. 29, P〈0.001）, in which the p H value of gastric juice after 3 d medication in the group C was significant higher than that in the other two groups with statistical difference（ F = 7. 14, P〈0. 05）; among 3 groups, the group C had the lowest occurrence rate of SU（ 7. 50%） and the group B had the highest occurrence rate of SU（ 17. 50%）,but the difference had no statistical significance（ Z =1. 83, P〉0.05）; the occurrence rates of adverse reactions such as diarrhea,myalgia,paropsia and dermatitis showed no statistical difference among 3 groups（ P〈0.05）. Conclusion Omeprazole, pantoprazole and lansoprazole all can effectively prevent SU with definite effect,safety and reliability.