洛美沙星静脉滴注致不良反应文献分析

Analysis on Adverse Reactions of Lomefloxacin by Intravenous Drip

目的通过对洛美沙星静脉滴注致不良反应的文献分析,为临床合理使用洛美沙星提供参考。方法分别以洛美沙星和不良反应为关键词,以精准为匹配检索CHKD期刊全文数据库(1994年至2012年)和CHKD博硕士学位论文全文数据库(2000年至2012年)发表的洛美沙星静脉滴注致不良反应病例的文献,对其进行整理、归纳和分析。结果洛美沙星的不良反应与性别无密切关系,临床表现多种多样,以神经系统反应最常见,其次为过敏性休克。结论随着洛美沙星在临床的广泛应用,其不良反应及用药安全应得到关注。用药前应详细询问过敏史,充分认识药物的不良反应,根据病原菌的性质合理用药,注意药物间的相互作用,做到安全、有效用药。

Objective To analyze the adverse reactions of intravenous drip of lomefloxacin to provide references for its rational use in clinic. Methods With lomefloxacin and adverse reactions as the key words respectively,the published literature on the cases of adverse reactions caused by intravenous drip of lomefloxaci was retrieved from the CHKD periodicals full- text database（ 1994- 2012） and the CHKD doctor and master＇s degree dissertation full- text database（ 2000- 2012） and performed the arranging,summing up and analyzing. Results The adverse reactions of lomefloxacin had no close relation with gender,the clinical manifestations were various,the neural system reactions were most common, followed by anaphylactic shock. Conclusion Along with the promotion of lomefloxacin in clinical application,its adverse reactions and medication safety should be paid attention to. Before using lomefloxacin in clinic,the allergic history should be inquired in detail and the adverse reactions should be fully cognized. According to the nature of the pathogen, lomefloxacin should be rationally used,and attention should be paid to the drug interaction for conducting safe and effective medication.