铜绿假单胞菌耐药率与抗菌药物使用强度的相关性研究

Antimicrobial resistance rate of Pseudomonas aeruginosa and it's correlation with antimicrobial use density

了解铜绿假单胞菌耐药率及其与住院患者抗菌药物使用强度（AUD）间的关系,为医院感染控制工作提供参考。方法对2011年7月—2013年12月某医院住院患者分离的铜绿假单胞菌耐药率及同期住院患者AUD进行监测,并对两者进行相关性分析。结果该院住院患者总AUD从2011年第三、四季度的73.61下降至2013年第三、四季度的41.33。住院患者AUD与铜绿假单胞菌耐药率相关性分析,相关系数r为-0.32~0.88,其中铜绿假单胞菌对氨曲南耐药率与氨曲南使用强度相关系数为0.88,其相关性具有统计学意义。结论住院患者AUD下降,铜绿假单胞菌的耐药率呈现下降趋势,提示临床应考虑抗菌药物的选择性筛选耐药。

Objective To realize antimicrobial resistance rate of Pseudomonas aeruginosa （P. aeruginosa） and it＇s correlation with antimicrobial use density（AUD）, and to provide reference for control of healtheare-assoeiated infec- tion. Methods From July 2011 to December 2013, antimicrobial resistance rate of P. aeruginosa isolated from hospi- talized patients and AUD of patients were monitored, and the correlation between them was analyzed. Results AUD of patients decreased from 73.61 in the third and fourth quarters of 2011 to 41.33 in the same quarters of 2013. Corre- lation coefficient of AUD and antimicrohial resistance rate of P. aeruginosa was - 0.32~0.88, correlation coeffi- cient of resistance rate of P. aeruginosa to aztreonam and aztreonam use density was 0.88,there was statistical sig- nificance. Conclusion AUD of hospitalized patients revealed a decreasing tendency, suggesting antimicrobial selec- tive resistance should he considered in clinic.