短暂性脑缺血发作进展为脑梗死危险因素分析

Analysis of risk factors associated with cerebral infarction due to transient ischemia attack

目的：探讨短暂性脑缺血发作（TIA）进展为脑梗死的危险因素。方法：选取129例TIA患者,其中32例在6个月内最终进展为脑梗死（脑梗死组）,97例病情未进展（TIA组）;对2组临床资料进行对比,并将所得数据进行统计学分析。结果：脑梗死组有高血压史、颈动脉不稳定斑块、糖尿病史、发作持续时间≥30 min和发作次数≥3次,均高于TIA组（P〈0.05-P〈0.01）。2组患者性别、有无吸烟史和有无冠心病史差异均无统计学意义（P〉0.05）。脑梗死组患者年龄大于TIA组（P〈0.05）。而2组患者空腹血糖、三酰甘油、胆固醇、低密度脂蛋白和血尿酸水平差异均无统计学意义（P〉0.05）。结论：TIA发作持续时间长、发作次数多,尤其有高血压病、糖尿病、高龄、颈动脉不稳定斑块者短期内进展为脑梗死的危险性较高。

Objective： To investigate the risk factors of transient ischemic attack（ TIA） evolving into cerebral infarction. Methods： The clinical data of 32 cases with TIA evolving into cerebral infarction（ cerebral infarction group） and 97 cases with TIA no-evolving into cerebral infarction（ TIA group） within 6 months were statistically analysed. Results： The indicators of hypertension,unstable carotid plaques,diabetes,duration of attack more than or equal to 30 minutes and attack frequency more than or equal to 3 times in cerebral infarction group were higher than those in TIA group（ P〈0. 05 to P〈0. 01）. The differences of sex,smoking history and coronary heart disease between two groups were not statistically significant（ P〉0. 05）. The patient age of cerebral infarction group was higher than that in TIA group（ P〈0. 05）. The differences of the levels of FBG,triglycerides,cholesterol,LDL and serum uric acid between two groups were not statistically significant（ P〉0. 05）. Conclusions： The incidences of TIA evolving into cerebral infarction in the patients with long lasting time and frequent attacking of TIA complicated with hypertension,diabetes,advanced age and unstable carotid plaques are higher.