摘要
卵巢癌是妇科常见的恶性肿瘤,多数卵巢癌患者就诊时已属晚期,丧失手术机会,化学治疗(化疗)是主要的治疗手段,然而对化疗药物的多药耐药是影响预后的主要因素。姜黄素能够从多种途径逆转卵巢癌多药耐药(MDR),而且不良反应小,近年来对其研究也越来越受到重视。该文较为全面地综述了卵巢癌MDR发生的机制及姜黄素逆转MDR的机制。
Ovarian cancer is a common gynecologic malignant tumor, and the majority of ovarian cancer patients are at advanced stages when diagnosed, which means loss of the surgery opportunity. Chemotherapy is the main treatment for ovarian cancer, however, multidrug resistance is the main factor influencing the prognosis. Study found that curcumin can reverse multidrug resistance in ovarian cancer with small toxicity. In recent years the research on it has been paid more and more attention. Here is to make a comprehensive review of the mechanisms of multidrug resistance in ovarian cancer and the reversal mechanism of curcumin.
出处
《医学综述》
2014年第23期4272-4274,共3页
Medical Recapitulate
关键词
姜黄素
卵巢癌
多药耐药
Curcumin
Ovarian cancer
Multidrug resistance
