贝那普利和贝尼地平联合治疗糖尿病肾病的临床疗效

Study on the Clinical Efficacy of Combined Therapy of Benazepril Benidipine for Patients with Diabetic Nephropathy

目的观察贝那普利和贝尼地平联合治疗2型糖尿病肾病的临床疗效。方法将2012年1月至2013年1月中国人民解放军北京军区北戴河疗养院收治疗的90例2型糖尿病肾病患者依据随机数字表法分为三组:A组30例口服贝尼地平4 mg,B组30例口服贝那普利10 mg,C组30例口服贝尼地平4 mg和贝那普利10 mg。疗程12周,观察三组治疗前后血压、血糖和肾功能的变化以及不良反应情况。结果治疗12周后,三组患者收缩压、舒张压、24 h尿蛋白均较治疗前下降(P<0.01);三组治疗前后血尿素氮、血肌酐、肌酐清除率、血清电解质(K+)和空腹血糖比较差异均无统计学意义(P>0.05)。三组不良反应发生率比较差异无统计学意义(P>0.05)。结论贝那普利、贝尼地平长期单独治疗均可有效降低血压和减少尿蛋白,两者联用在治疗2型糖尿病肾病的治疗上可增加疗效并减少不良反应。

Objective To observe the clinical efficacy of combined therapy of benazepril and benidipine for patients with type 2 diabetic nephropathy. Methods A total of 90 patients with type 2 diabetic nephropathy admitted in PLA Beijing Military Region Beidaihe Sanatorium from Jan. 2012 to Jan. 2013 were randomly divided into three groups ： group A （ patients were given 4 mg of Benidipine）, group B （ patients were given 10 mg of benazepril） ,and group C（patients were given 4 mg of benidipine and 10 mg of benazepril）. After an average of 12 weeks follow-up, blood pressure, blood sugar level, kidney function, and adverse reactions of the three groups were observed and studied. Results After 12 weeks of treatment, systolic pressure, diastolic pressure,24-h urinary protein of the three groups all decreased（P 〈 0.01 ）. In the three groups before and after treatment, levels of blood urea nitrogen, serum creatinine, creatinine clearance rate, serum electrolyte （ K＋ ） and fasting blood glucose had no statistically significant differences （ P 〉 0.05 ）. The incidence of adverse reactions of the three groups had no statistically significant difference （ P 〉 0.05 ）. Conclusion Long-term application of single benazepril, or benidipine can effectively lower the blood pressure and reduce urinary protein; while the combined therapy of the two drugs can improve the efficacy of the treatment for type 2 diabetic nephropathy and reduce adverse reactions.