综合疗法联合神经节苷脂治疗中老年重症脑卒中的疗效

The Curative Effect of Comprehensive Therapy Combined with Ganglioside Sodium in the Treatment of Severe Stroke in Elderly Patients

目的探讨综合疗法联合神经节苷脂治疗中老年重症脑卒中的疗效。方法选择2010年9月至2012年9月在重庆市第五人民医院确诊为中老年重症脑卒中患者150例,利用随机数字表法分为试验组和对照组,每组75例,试验组采用综合疗法联合神经节苷脂法,对照组采用综合疗法。比较两组患者治疗前后的血清参数-神经元特异性烯醇化酶(NSE)、超氧化物岐化酶(SOD)以及血流动力学参数,并分析神经功能缺损程度(NDS)、日常生活活动量(ADL)等临床指标。结果试验组经治疗后的血清中NSE、ODS的浓度显著低于对照组[(13.96±1.18)μg/L vs(25.16±0.45)μg/L,(8.39±0.63)μmol/L vs(14.71±0.66)μmol/L,P<0.05];全血高切黏度、全血低切黏度显著低于对照组[(3.68±1.05)m Pa·s vs(5.67±1.34)m Pa·s,(6.95±0.72)m Pa·s vs(9.73±0.86)m Pa·s,P<0.05],红细胞沉降率显著高于对照组[(26.2±1.1)mm/h vs(17.9±1.2)mm/h,P<0.05];NDS评分显著低于对照组[(12.2±2.1)分vs(23.5±1.8)分,P<0.05];ADL评分显著高于对照组[(75.5±1.2)分vs(57.4±1.4)分,P<0.05]。结论综合疗法联合神经节苷脂能够改善病变的血管,修复受损的神经系统,临床应用价值高。

Objective To investigate the efficacy of comprehensive therapy combined with ganglioside sodium in the treatment of severe stroke in elderly patients. Methods A total of 150 cases of elderly patients with severe stroke diagnosed in Chongqing Fifth People＇s Hospital from Sep. 2010 to Sep. 2012 were selected and randomly divided into group A and group B by the random-number table method. Each group had 75 cases. Group A was given comprehensive therapy in combination with ganglioside, and group B was treated by only the comprehensive therapy. The neuron-specific enolase （ NSE ）, super oxygen disproportionation enzyme （SOD） and the parameters of hemorrheology in two groups before and after treatment were compared. And the clinical indicator of degree of nervous functional defects （NDS）, daily life activity（ADL） of the two groups were analyzed. Results The serum concentration of NSE and SOD of group A after treatment was significantly lower than group B [ （ 13.96 ± 1.18 ） μ g/L vs （ 25.16 〉 0.45 ） μg/L, （ 8.39 ± 0.63 ） μmol/L vs （14.71 ± 0.65 ）p.mol/L, P 〈 0. 05 ] ; and the whole blood high shear viscosity, whole blood low shear viscosity of hemorheology in group A after the treatment was lower than group B [ （ 3.68 ± 1.05 ） mPa · svs （5.67 ± 1.34）mPa · s, （6.95 ±0.72）mPa ·s vs（9.73 ±0.86）mPa · s, P 〈0.05] ;the erythrocyte sedimentation rate of group B was higher than group A [ （26.2 ± 1.1 ）mm/h vs （7.9 ± 1,2 ） mm/h,P 〈 0.05 ] ; the NDS score of group A after treatment was significantly lower than group B[ （ 12.2 ± 2.1 ） vs（23.5 ± 1.8 ）, P 〈 0.05 ], the ADL score of group A was significantly higher than group B [ （75.5 ±1.2 ） vs （57.4 ± 1.4）, P 〈 0.05 ]. Conclusion The comprehensive therapy combined with ganglioside sodium can improve the condition of the diseased blood vessel, repair the damaged nervous system, thus is of high clinical application value.