孤独症谱系障碍儿童的视觉诱发电位研究

Study on visual evoked potential in children with autism spectrum disorder

目的探索孤独症谱系障碍儿童棋盘格翻转视觉诱发电位的特点。方法采用美国精神障碍统计与诊断手册第四版(DSM-Ⅳ)诊断标准入组孤独症谱系障碍组12人;正常对照组12人。对所有对象进行5个不同空间频率刺激下的视觉诱发电位测试。结果 1)5个不同的空间频率刺激下的P100波的潜伏期孤独症谱系障碍组均较对照组延长,差异有显著统计学意义(P<0.05)。2)5个不同的空间频率刺激下的P100波的振幅孤独症谱系障碍组均较对照组减小,差异有显著统计学意义(P<0.05)。结论孤独症谱系障碍儿童棋盘格翻转视觉诱发电位中P100波潜伏期延长,波幅减小,表明其视网膜神经节细胞至视觉中枢的信息处理存在着异常,视觉传导通路中小细胞通路异常。

Objective To study the Pattern Reversed Visual Evoked Potential （PRVEP ）characteristics of children with autism spectrum disorder（ASD）. Methods The ASD group of 12 children were diagnosed by DSM-Ⅳ.The control group were 12 normal children.They were tested by PRVEP at five levels of spatial frequency. Results 1）The latencies of P100 wave were significantly prolonged at all five spatial frequency in the ASD group compared with the control group （P〈0.05）.2） The amplitudes of P100 in the ASD group were significant smaller than those in the control group at all five spatial frequency （P〈0.05）. Conclusions The latencies of P100 wave are longer and the amplitudes are smaller in ASD group than those in control group.It is indicated that the transmission function of retinal ganglion cells to the visual centers deal difficultly and the parvocellular pathway is deficit in the children with ASD.