期刊文献+

普伐他汀药代动力学与其他药物的相互作用研究概述 被引量:2

下载PDF
导出
摘要 普伐他汀是新一代羟甲基戊二酰辅酶A还原酶抑制剂,能有效降低血清胆固醇,改善血脂。由于其亲水性强、选择性高、代谢途径为非酶代谢,所以与同类降脂药相比,具有血浆蛋白结合率低、不良反应少、药物相互作用少等优势,是具有良好临床应用前景的降脂药物。因此,本文对普伐他汀的药代动力学性质及其与其他药物的相互作用进行总结,为临床用药的安全性和有效性提供参考。
出处 《西南军医》 2014年第6期679-681,共3页 Journal of Military Surgeon in Southwest China
基金 成都军区总医院院管课题项目(2013YG-B092)
  • 相关文献

参考文献19

  • 1Pan HY,DeVault AR,Swites BJ,et al.Pharmacokineticsand pharmacodynamics of pravastatin alone and with cho-lestyramine in hypercholesterolemia[J].Clin Pharmacol Ther,1990,48:201-207.
  • 2Sasahara K,Kawabata K,Nakaya N,et al Phase I study of CS-514,an inhibitor of HMG-CoAreductase II:pharmaco-kinetics of CS-514 in healthy volunteers[J].RinshoIyaku,1988,4:45-65.
  • 3Sigurbjomsson S,Kjartansdottir T,Johannsson M,et al.Apharmacokinetic evaluation of pravastatin in mid-dle-aged and elderly volunteers[J].Eur J Drug Metab Pharmacokinet,1998,23:13-18.
  • 4Pan HY,DeVault AR,Brescia D,et al.Effect of food onpravastatin pharmacokinetics and pharmacodynamics[J].Int J Clin Pharmacol Ther Toxicol,1993,31:291-294.
  • 5Pan HY,Waclawski AP,Funke PT,et al.Pharmacokineticsof pravastatin in elderly versus young men and women[J].Ann Pharmacother,1993,27:1029-1033.
  • 6Botti RE,Triscari J,Pan HY,et al.Concentration ofpravastatin and lovastatin in cerebrospinal fluid in healthysubjects[J].Clin Neuropharmacol,1991,14:256-261.
  • 7Ito MK.Effects of extensive and poor gastrointestinal me-tabolism on the pharmacodynamics of pravastatin[J].J Clin Pharmaco,1998,38:331-336.
  • 8Jacobson TA.Comparative pharmacokinetic interactionprofiles of pravastatin,simvastatin,and atorvastatin whencoadministered with cytochrome P450 inhibitors[J].TheAmerican Journal of Cardiology,2004,94(9):1140-1146.
  • 9Quion JAV,Jones PH.Clinical pharmacokinetics of pravas-tatin[J].Clin Pharmacokinet,1994,27:94-104.
  • 10Jacobsen W,Kirchner G,Hallensleben K,et al. Small in-testinal metabolism of the 3-hydroxy-3-methylglutary 1-co-enzyme A reductase inhibitor lovastatin and comparisonwith pravastatin[J].J Pharmacol Exp Ther,1999,291:131-139.

同被引文献24

  • 1ChP(中国药典)(二部)[M].2015:1429-1432.
  • 2HeFnawy MM, MoHaMed MS, Abounassif MA, et al. High-performance liquid chromatography and derivative speetrophotometry for simultaneous determination of pravastatin and fenofibrate in the dosage form [ J ]. Ac- ta Pharm, 2014, 64(4) : 433-446.
  • 3Zhu Z, Neirinck L. High-performance liquid ehroma-tography coupled with negative ion tandem mass spec- trometry for determination of pravastatin in human plasma[ J ]. J Chromatogr B, 2003, 783 ( 1 ) : 133- 140.
  • 4Neuvonen PJ, Baekman JT, Niemi M. Pharmacokinet- ic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin [J]. Clin Pharmacokinet, 2008, 47(7) : 463-474.
  • 5Onal A, Sagirli O. Development of a selective LC method for the determination of pravastatin sodium [ J ]. Chromatographia, 2006, 64 (3/4) : 1-6.
  • 6Deng S, Chen XP, Cao D, et al. Effects of a concom- itant single oral dose of rifampicin on the pharmacoki- netics of pravastatin in a two-phase, randomized, sin- gle-blind, placebo-controlled, crossover study in healthy Chinese male subjects [ J ]. Clin Ther, 2009, 31(6) : 1256-1263.
  • 7Bauer S, Mwinyi J, Stoeckle A, et al. Quantification of pravastatin in human plasma and urine after solid phase extraction using high performance liquid chroma- tography with ultraviolet detection [ J ]. Chromatogr B, 2005, 818(2) : 257-262.
  • 8Keri V, Szabo C, Arvai EN, et al. Novel forms of pravastatin sodium [ P]. WO: 0197633 A1,2007-08- 23.
  • 9Zlatko Pflaum. Crystals of the sodium salt of pravasta- tin [P]. AU. 200060109B2, 2001-03-05.
  • 10Jia CY, Liu QX, Zhang MJ, et al. Polymorphic trans- formation of pravastatin sodium monitored using com- bined online FBRM and PVM[J]. Org Pro Res Dev, 2008, 12(6): 1223-1228.

引证文献2

二级引证文献16

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部