冠心病危险因素的Meta分析

Meta-analysis on the risks factors of coronary heart diease

目的 定量综合评价中国人群冠心病发生的主要危险因素,为预防决策提供依据.方法 利用Meta分析方法对国内2000～2013年14年间关于冠心病危险因素的研究文献进行定量综合分析,用随机效应模型计算合并OR值及其95％的置信区间（95％ CI）.结果 20个研究共6948例病例和116165例对照被纳入Meta分析,入选研究有较高的质量,采用随机效应模型进行数据合并,各因素合并OR值及95％cI分别为：高血压病3.403（2.484～4.323）,冠心病家族史2.497（2.097～2.897）,吸烟史1.785（1.504～2.065）,糖尿病2.050（1.061～2.490）,肥胖1.478（1.024～1.937）,高脂血症2.084（1.675～2.493）,高胆固醇血症1.962（1.461～2.463）.结论 高血压病、冠心病家族史、吸烟史、糖尿病、肥胖、高脂血症、高胆固醇血症均为中国人群冠心病发生的主要危险因素.

Objective To quantitatively evaluate the main factors related to the incidence of coronary heart disease in Chinese people and provide evidence for prevention of decision-making on coronary heart disease. Methods The literatures of epidemiological studies on risk factors of coronary heart disease from 2000 to 2013 were retrieved and analyzed synthetically by Meta-analysis. Random effect model were selected to calculate the pooled OR and its corresponding 95% Confidence Interval. Results 20 studies, a total of 6948 cases and 116165 controls were included in Meta-analysis and these studies included had high quality.. The pooled odds ratio for hypertension was 3. 403 （2. 484~4. 323）, family his- tory of CDH 2. 497 （2. 097~2. 897）, smoking 1. 785 （1. 504~2. 065）, diabetes mellitus 2. 050 （1. 061~2. 490）, obesity 1. 478（1. 024~1. 937）, hyperlipemia 2. 084 （1. 675~2. 493）, hypercholesteremia 1. 962 （1. 461~2. 463）, respectively. Conclusion Hypertension, family history of CDH, smoking, diabetes mellitus, obesity, hyperlipemia and hypercholesteremia were the main factors influencing the incidence of coronary heart disease in Chinese people.