生大黄对重症脑卒中患者肠黏膜屏障功能的保护作用

The protective effect of rhubarb on intestinal mucosal barrier in patients with severe stroke

目的观察生大黄对重症脑卒中患者血浆D-LAC的影响。方法前瞻、随机抽取符合入选条件的重症脑卒中患者40例,分为治疗组21例和对照组19例,治疗组给予生大黄15g/d,对照组给予常规治疗,于治疗前和治疗后测定患者血浆D-LAC。结果治疗前治疗组患者的血浆D-LAC水平[(59.50±10.43)mmol/L]与对照组[(61.32±9.56)mmol/L]比较,差异无显著性(P>0.05);治疗后治疗组血浆D-LAC水平[(51.18±8.47)mmol/L]较对照组[(56.98±6.99)mmol/L]明显下降(P<0.05)。结论生大黄能改善重症脑卒中患者肠黏膜通透性,保护肠道功能,减少肠道细菌移位,减少肠源性感染的发生。

Objective To investigate the effects of raw rhubarb （RR） on levels of plasma D-lactate in patients with Severe Stroke. Methods 40 patients with severe stroke were randomly divided into RR group （n=21, treated with RR 15 g/d） and the control group （n=19, treated with conventional treatment）. Plasma D-lactate were determined before and after treatment. Results Before treatment, there was no significant difference in the levels of plasma D^lactate between the two groups （59.50±10.43） mmol/L vs （61. 32±9. 56） mmol/L,P〉0.05. However, after treatment, The indexes in the RR group were significantly lower than those in the control group （51.18±8.47） mmol/L vs （56.98±6.99） mmol/L, P〈0.05. Conclusion RR could ameliorate the intestinal permeability and reduce the shifting of intestinal bacteria, so as to reduce the infection of the intestinal in patients with Severe Stroke.