高血压及高脂血症与颈动脉粥样硬化的相关性分析

Analysis of the relationship between hypertension,hyperlipidemia and carotid artery atherosclerosis

目的探讨高血压、高脂血症与颈动脉粥样硬化的相关性。方法随机选取320例来院体检人群,测量其血压以及血脂水平,并将其分为高血压组、高脂血症组、高血压合并高脂血症组及对照组,分析各组颈动脉粥样硬化发生率以及测量其颈动脉内膜-中膜厚度(IMT),分析颈动脉粥样硬化与高血压、高脂血症的相关性。结果高血压组颈动脉粥样硬化斑块的发生率为22.22%,高脂血症组发生率为24.68%,高血压合并高血脂组发生率为36.58%,均明显高于对照组的7.50%(均P<0.05);且高血压合并高脂血症组发生率明显高于单纯高血压及单纯高脂血症组(均P<0.05)。高血压、高脂血症组与高血压合并高脂血症组的颈动脉内膜-中膜增厚与对照组有显著差异(均P<0.05)。结论高血压、高脂血症是颈动脉粥样硬化斑块形成的重要因素,且高血压合并高血脂可加重动脉粥样硬化的病变程度。

Objective To study the correlation between hypertension, hyperlipidemia and carotid artery atherosclerosis. Methods 320 patients were randomly divided into hypertension group, hyperlipemia group, hypertension and hyperlipidemia group and control group. The blood pressure, blood lipid levels and the incidence of carotid artery atherosclerosis and the carotid intima-media thickness （IMT） were observed. Results The incidence rate of plaque of carotid atherosclerosis in hypertension group （22.22%）, hyperlipemia group（24.68%） and hypertension complicated with hyperlipemia patients（36.58%） were higher than that in control group （7.50%） （P〈0.05）. The hypertension and hyperlipidemia occurred higher than the pure hypertension and hyperlipidemia group （P〈0.05）. Hypertension, hyperlipidemia and hypertension complicated with carotid intima hyperlipidemia group of membrane thickening and the control group had significant difference （P〈0.05）. Conclusion Hypertension, hyperlipidemia is an important factor in the formation of carotid artery atherosclerotic plaque, and the severity of hypertension complicated with hyperlipemia can aggravate atherosclerosis.