套扎术联合硬化术治疗食管胃底静脉曲张破裂出血的疗效观察

Ligation combined with sclerotherapy in treatment of esophageal variceal bleeding

目的探讨套扎术联合硬化术治疗肝硬化食管胃底静脉曲张出血的临床疗效。方法按入院的先后顺序将98例肝硬化食管胃底静脉曲张出血患者随机分为观察组和对照组各49例,对照组采用套扎术进行治疗,而观察组采用套扎术联合硬化术治疗。记录并比较两组患者的止血成功率、静脉曲张率、再出血率、死亡率及并发症发生率等各项临床指标。结果观察组术后静脉曲张率、再出血率和死亡率分别为10.2%、61.2%和8.2%,明显低于对照组的36.7%、87.8%和30.6%;各项并发症发生率也明显低于对照组,组间差异均具有统计学意义(均P<0.05);而观察组的术后止血成功率(98.0%)与对照组(95.9%)比较,差异无统计学意义(P>0.05)。结论套扎术联合硬化术治疗肝硬化食管胃底静脉曲张出血可提高治疗效果,降低并发症发生率,具有重要的临床推广应用价值。

Objective To explore the clinical efficacy of llgatlon combined with sclerotherapy in treatment of esophageal variceal bleeding. Methods According to the order of admission, 98 cirrhotic patients with esophageal varieeal bleeding were randomly divided into observation group and the control group（n= 49）. The control group received ligation therapy treatment, while the observation group received ligation combined sclerosis therapy. The clinical parameters including the success rate of bleeding, varicose veins rate, rebleeding rate, mortality and morbidity were recorded and com pared between groups. Results Varicose rate, varicose veins rate, rebleeding and mortality rates of observation group were significantly lower than that of the control group. The incidence of disease of observation group was significantly lower than that of the control group （P〈0.05）. The success rate of postoperative bleeding （98.0%） in the observation group was not statistically significant different from that of the control group （95.9%）. Conclusion Ligation combined with sclerotherapy in treatment of esophageal variceal bleeding can improve the therapeutic effect and reduce complications.