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上皮间质转化与肿瘤耐药 被引量：4

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摘要 化疗是恶性肿瘤最常用的治疗手段之一,但肿瘤发生获得性耐药是阻碍临床疗效,导致大多数患者治疗失败的主要原因。近年来大量研究发现,肿瘤细胞上皮间质转化(epithelial to mesenchymal transition,EMT)不仅促进肿瘤细胞的侵袭和转移,也在多种肿瘤发生化疗耐药中发挥重要作用。肿瘤细胞EMT的发生受复杂的信号通路调控,这些信号通路也在诱导肿瘤细胞耐药中起重要作用。本文综述了肿瘤细胞发生EMT与耐药相关机制的研究进展。
作者 黄迎娣 崔蕾 黄利鸣 王艳林
机构地区 三峡大学医学院分子生物学研究所
出处 《东南国防医药》 2014年第6期624-628,共5页 Military Medical Journal of Southeast China
基金 国家自然科学基金项目(81374024) 湖北省自然科学基金项目(2013CFA079)
关键词 上皮间质转化 肿瘤 化疗 耐药 信号通路
分类号 R730.5 [医药卫生—肿瘤]
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参考文献36

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二级参考文献64

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共引文献112

同被引文献54

引证文献4

二级引证文献14

东南国防医药
2014年 第6期

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