摘要
目的 探讨急性肾损伤合并自身免疫性溶血性贫血的临床特点.方法 分析2例急性肾损伤合并自身免疫性溶血性贫血患者的临床资料,结合文献复习此类疾病的临床特点及诊治思路.结果 2例患者均表现为严重的急性肾损伤、进行性加重的贫血,促红素、铁剂、叶酸补充等常规纠正贫血治疗无效,直接Coombs阳性,外周血网织红细胞升高,血清乳酸脱氢酶、血清胆红素正常,类固醇激素治疗有效.结论 急性肾损伤合并进行性贫血需考虑是否合并自身免疫性溶血,及时给予类固醇激素治疗临床效果显著.
Objective To investigate the clinical characteristics of patients suffering from autoimmune hemolytic anemia（AIHA） associated with acute kidney injury （AKI）.Methods The clinical data of 2 case patients with AIHA and AKI in the People＇s Hospital of Huadu District of Guangzhou was analyzed and associated literatures were reviewed.Results Two patients presented with severe anemia,raised reticulocyte count,positive Coomb＇s test,and acute renal failure.They were no effect therapy when treatment with agent of erythropoietin （EPO）,iron or folic acid.The level of serum indirect bilirubin was at normal range.Liver function and serum LDH were normal too.However,treatment with corticosteroids was effective.Conclusion When patients suffering AKI occur worsening anemia,AIHA probably should be concerned.Treatment with corticosteroids early is effective.
出处
《中国综合临床》
2014年第12期1259-1261,共3页
Clinical Medicine of China
基金
广州市医学重点学科建设项目（2013-2015）
广州市花都区科技计划项目（13-HDWS2003）
