生长抑素治疗急性胰腺炎的临床效果分析

Analysis of the Clinical Effectiveness of Somatostatin in the Treatment of Acute Pancreatitis

目的:分析生长抑素治疗急性胰腺炎的临床疗效。方法:选择急性胰腺炎患者88例,随机分为治疗组和对照组各44例,对照组给予禁食、胃肠减压、调整水、电解质及酸碱平衡、常规使用抗生素、补充有效血容量、保持肠外营养等对症支持治疗。同时应用低分子右旋糖酐、复方丹参、质子泵抑制剂等静脉滴注。治疗组在此基础上加用生长抑素3 mg加入5%葡萄糖注射液静脉滴注。比较两组腹痛及腹部深压痛消失时间及临床治愈率、治愈时间及死亡率。结果:对照组腹痛及腹部深压痛消失时间(88.3±3.6)h和(170.6±39.1)h与治疗组(49.1±12.1)h、(102.1±38.3)h比较差异有统计学意义(P<0.05)。对照组治愈率81.82%(36/44),治愈时间(23.6±4.9)d,死亡率18.18%(8/44)。治疗组治愈率97.73%(43/44),治愈时间(16.3±5.5)d,死亡率2.27%(1/44)。治疗组临床治愈率、治愈时间及死亡率与对照组比较差异有统计学意义(P<0.05)。结论:生长抑素对急性胰腺炎的治疗效果显著,可在一定程度上控制病情的发展。

Objective：To analyze the clinical efficacy of somatostatin in acute pancreatitis.Method： 88 patients with acute pancreatitis were randomly divided into treatment group and control group, control group（44 cases） was given fasting, gastrointestinal decompression, maintaining water, electrolyte and acid-base balance, the routine use of antibiotics, adding blood volume, maintaining parenteral nutrition and other symptomatic supportive treatment.At the same time low molecular weight dextran, Danshen, proton pump inhibitors, such as intravenous infusion were applied.Treatment group（44 cases） was treated with somatostatin 3 mg in 5% glucose intravenous injection in addition.The abdominal pain and abdominal tenderness disappeared deep time and the clinical cure rate,cure time and mortality were compared.Result：In the control group, abdominal pain and abdominal tenderness disappeared time（88.3±3.6） h and（170.6±39.1） h comparing with the treatment group（49.1±12.1） h,（102.1±38.3） h were with statistical significant（P〈0.05）.Cure rate was 81.82%（36/44） in the control group, cure time was（23.6±4.9） d, mortality was 18.18%（8/44）.In the treatment group： the cure rate was 97.73%（43/44）, cure time was（16.3±5.5） d, the mortality rate was 2.27%（1/44）.Differences between the two groups had statisticalsignificance（P〈0.05）.Conclusion：The therapeutic effect of somatostatin on acute pancreatitis is significant,it can control the disease progresses in some extent.