糖皮质激素降阶梯疗法治疗慢性湿疹临床疗效

The Clinical Efficacy of Glucocorticoid De-escalation Therapy in Chronic Eczema

目的:观察糖皮质激素降阶梯疗法治疗慢性湿疹临床疗效。方法:选取2013年2月-2014年4月笔者所在医院收治的100例慢性湿疹患者为研究对象,随机将其分为复方丙酸氯倍他索软膏组(对照A组)、糠酸莫米松软膏组(对照B组)以及氟芬那酸丁酯软膏组(对照C组)、试验组,每组25例。试验组采用降阶梯疗法,用药依次为复方丙酸氯倍他索软膏、糠酸莫米松软膏、氟芬那酸丁酯软膏。对比各组治疗效果。结果:试验组与对照A组疗效比较差异无统计学意义(P>0.05);试验组治疗效果明显优于对照B、C两组,差异有统计学意义(P<0.05);试验组不良反应发生率明显低于对照A组,差异有统计学意义(P<0.05)。结论:对于慢性湿疹患者而言,降阶梯疗法是一种理想的治疗方案,疗效确切,不良反应较少,值得推广应用。

Objective：To observe the clinical efficacy of glucocorticoid de-escalation therapy in chronic eczema.Method：100 cases of chronic eczema in our hospital from February 2013 to April 2014 were selected for the study.According to randomly methods,they were divided into Compound Clobetasol Propionate Ointment group（control A group）,Mometasone Furoate Ointment group（control group B） and Flufenamic Acid Ester Ointment group（control group C）,and experimental group,25 cases of each group.The experimental group（25 cases） were given De-escalation therapy,medication followed Compound Clobetasol Propionate Ointment,Mometasone Furoate Ointment,Ointment Flufenamic Acid Ester Ointment.Treatment effects of each group were observed and statistically analyzed.Result：The difference between the experimental group and the control group A had no significant effect（P〉0.05）.The experimental group of treatment effect was significantly better than the control group B and C,there were statistical significance（P〈0.05）.The experimental group incidence of adverse reactions was significantly lower than the control group A（P〈0.05）.Conclusion：For patients with chronic eczema,de-escalation therapy is an ideal treatment plan,it is efficacy,fewer adverse reactions,should be introduced.