摘要
以紫杉醇丁二酸酯为原料,二苯基-N-琥珀酰亚胺磷酸酯为催化剂,合成了中间体N-羟基丁二酰亚胺紫杉醇丁二酸酯(3);3与游离奥曲肽偶联得紫杉醇-奥曲肽偶联物,纯度98%,其结构经ESI-MS确证。
An intermediate（ paclitaxel 2＇-succinyl-NHS,3） was obtained by the reaction of paclitaxel2＇-succinate with SDPP,using SDPP as the catalyst. The paclitaxel-octreotide conjugate in purity of98% was synthesized by coupling reaction of 3 with octreotide. The structure was confirmed by ESIMS.
出处
《合成化学》
CAS
CSCD
北大核心
2014年第6期840-842,共3页
Chinese Journal of Synthetic Chemistry
基金
东南大学重大科学研究引导基金资助项目(KJ20100493)
