茉莉酸类的抗癌活性及其作用机制

Anti-cancer activities and mechanism of jasmonates

茉莉酸类属于植物激素,能介导植物对外界伤害和病原菌侵染做出的应激防御反应,并对哺乳类动物癌细胞表现出抗癌活性。茉莉酸甲酯(MJ)是天然茉莉酸类中最有效的抗癌衍生物,能抑制癌细胞的增殖,诱导癌细胞死亡。茉莉酸类还具有引起基因表达异常等其他抗癌活性。本文通过回顾近年来茉莉酸类作为抗癌药物的研究进展,对茉莉酸类的抗癌活性及其作用机制进行了简单介绍。

Jasmonates is a class of plant stress hormones that mediates the defense response to mechanical and infectious insults with toxic activities toward mammalian cancer cells.As the most effective anti-cancer derivative among natural j asmonates,methyl j asmonate（M J）inhibits the proliferation and induces cell death in various human and murine cancer cell lines.Furthermore,jasmonates is capable of altering gene expression.The author summarizes over a decade of research on jasmonates as anti-cancer agents to describe the anti-cancer activities and its mechanism.