摘要
蟾酥由蟾蜍表皮腺体的分泌物经干燥而成。作为一种传统中药,其所含化学成分复杂,能清热解毒、醒脑开窍、化结溃坚;具有降压、增强心肌收缩力、增加冠状动脉流量、抗肿瘤、麻醉等药理作用。临床中广泛用于心血管系统、呼吸系统、五官、外科等疾病的治疗;作为有毒中药,其量效关系、毒性成分、中毒剂量和毒理机制等问题亦不容忽视。试从蟾酥的化学成分、药理作用及其机制、毒理作用、不良反应、炮制工艺、药动学等方面对其进行初步总结,为深入研究蟾酥的药理作用及复方制剂提供参考。
Bufonis Venenum is made by toad skin gland secretion after drying. As a kind of Chinese materia medica （CMM）, it contains complex chemical composition and has these pharmacological effects： to remove toxic heat, wake up the brain orifices, eliminate the mass, step-down blood pressure, increase myocardial contraction force and coronary artery blood flow, and use for antitumor and anesthesia. It is widely used in diseases in clinic such as cardiovascular, respiratory, facial features, and surgical treatment. While, as toxic CMM, the concentration-response relationship, toxic ingredients, toxic dose, and poisoning mechanism should not be ignored also. The author preliminarily summaries its effects from composition, pharmacological effects and mechanisms, adverse reactions, processing technology, and pharmacokinetics, and provides the references for its further pharmacological study and compound preparation development.
出处
《中草药》
CAS
CSCD
北大核心
2014年第21期3185-3189,共5页
Chinese Traditional and Herbal Drugs
基金
"重大新药创制"科技重大专项课题(子课题):创新药物研究开发技术平台建设-心脑血管疾病中药新药临床评价技术平台及规范研究(2012ZX09303-010-001)
关键词
蟾酥
蟾毒
蟾毒配基
蟾毒灵
不良反应
Bufonis Venenum
toadpoison
bufogenins
bufalin
adverse reaction
