当归不同部位入药功效取向差异的化学物质基础与药性关联性研究

Study on chemical materials and drug nature association of efficacy orientation of different parts from Angelicae Sinensis Radix

以中药方剂数据库为基础,检索其中包含当归不同部位入药的方剂。应用适宜的数据挖掘技术,统计分析当归不同入药部位的药性特点及其适应病证的变化规律。结合当归组织结构、当归不同部位化学成分分布特点,以及药效学报道,探讨当归不同入药部位功效取向差异机制及其应用病证的变化规律。结果显示,当归不同部位入药功效取向差异的化学物质基础与药性具有较高的关联性。当归不同部位临床用药的趋向性与古人所述"归头止血、归身补血、归尾活血、全当归活血补血"之结论基本一致。为当归不同入药部位的临床科学合理用药提供一定的研究基础和参考。

Based on Traditional Chinese Medical Formulae Database, all prescriptions including different parts from Angelicae Sinensis Radix （ASR） were searched. Applying appropriate data mining technology, the herbal property and rule of indications of different medicinal parts of ASR were analyzed from statistical data. Combining with the tissue characteristics, chemical constituents distribution, and related pharmacodynamics reports of different parts of ASR, authors probed into the efficacy orientation mechanism of different parts of ASR and the rule of applying to disease with syndrome. The results revealed high correlation between property and chemical materials of efficacy orientation of different ASR parts. The tendency of clinical effects from statistical data was nearly consistent with the ancient conclusion, which means ＂The head of ASR was used mainly to stop bleeding, the body of ASR was good for regulating and nourishing blood, and the tail of ASR was utilized primarily to promote blood circulation＂. This research could provide the scientific basis for clinical rational use of different parts of ASR.