丹红注射液对冠状动脉介入围术期心肌损害的保护作用

Protective effect of Danhong injection on perioperative myocardial damage in patients undergoing percutaneous coronary intervention

目的探讨丹红注射液对冠状动脉介入围术期心肌损害的保护作用。方法将择期行冠状动脉介入治疗(PCI)的冠心病患者70例分为治疗组和对照组,治疗组在综合治疗的基础上加用丹红注射液,对照组则不使用丹红注射液,比较两组患者术前、术后8、24h心肌损伤标志物,包括肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)及肌钙蛋白I(Tn-I)。结果 PCI术后8 h两组测定的CK、CK-MB及Tn-I均较术前明显升高(P<0.05),但治疗组较对照组低(P<0.01);PCI术后24h对照组CK、CK-MB及Tn-I水平仍高于术前(P<0.05),治疗组与术前比较差异无统计学意义(P>0 05),且低于对照组(P<0.05)。结论丹红注射液对冠心病患者PCI围术期心肌损害有保护作用。

Objective To investigate the protective effect of Danhong injection on perioperative myocardial damage in patients undergoing percutaneous coronary intervention（PCI）. Methods Seventy patients with coronary heart disease undergo-ing elective PCI in our hospital were randomly divided into two groups：patients in Danhong group received Danhong injection in addition to basic treatment and those in control group received basic treatment only. The myocardial injury markers CK, CK- MB and cTnI were detected before and 8h, 24h after PCI. Results CK, CK- MB and cTnI levels in both groups 8h after PCI were significantly higher than those before operation （P〈0.05）, but these markers in Danhong group were lower than those in control group（P〈0.01）. The levels of myocardial injury markers 24h after PCI in control group were stil higher than those before PCI, but those markers in Danhong group were no difference to preoperative levels （P〉0.05）, and lower than those in control group （P〈0.05）. Conclusion Danhong injection has a protective effect on perioperative myocardial damage in patients with coronary heart disease undergoing PCI.