强心苷类药物药动学研究进展

Research progress on pharmacokinetics of cardiac glycosides

强心苷类化合物药理活性广泛,临床上主要用于治疗慢性心力衰竭及某些类型的心律失常,在抗肿瘤方面也疗效显著。通过综述近年来国内外涉及强心苷类药物药动学研究的文献,归纳其体内外的吸收、分布、代谢、排泄行为特征,重点对该类药物的代谢情况进行总结,为强心苷类药物的安全使用及新药开发提供了一定参考依据。

Cardiac glycosides are proven to be effective in the clinical treatment for chronic heart failure and certain types of arrhythmia, especially for antitumor treatment. This paper focused on the research progress on pharmacokinetics of cardiac glycosides in recent years, elucidated the behaviors of absorption, distribution, metabolism, and excretion in vivo and in vitro, and summarized the metabolism of this kind of drug, aiming to provide an evidence for new drug research as well as a reference for the clinical safe use of these drugs.