炎性因子浓度与脓毒症患者病情程度量化关系的关联性分析

Correlation analysis between the concentration of inflammatory cytokines and the degree of sepsis

目的探讨脓毒症各类型患者血液中白细胞介素6(IL-6)、C反应蛋白(CRP)、降钙素原(PCT)浓度与脓毒症病情严重程度之间的定量关系。方法选择符合诊断脓毒症标准的患者100例,按病情严重程度分组,并于入院当日记录每例患者的基本资料及疾病严重程度指数(APACHEⅡ)评分。抽取静脉血液6 ml分别测定血液中IL-6、CRP、PCT浓度。结果经多分类Logistic回归模型分析显示患者的病情严重程度与PCT浓度水平、APACHEⅡ评分有关联。结论炎性因子PCT浓度及APACHEⅡ评分对评估脓毒症患者病情严重程度有一定指导价值。

Objective To investigate the quantitative relationship between the concentration of IL-6, CRP, PCT in all kinds of sep- sis patients＇ blood and the severity degree of sepsis. Methods One hundred sepsis patients were selected, then grouped according to the severity of the disease and scored according to basic information of each patient and APACHE Ⅱ. To extract venous blood 6 ml and measure the concentration of IL-6, CRP and PCT. Results Logistic regression model showed that the severity degree of sepsis is associated with PCT and APACHE fi in 100 standard patients. Conclusion The concentration of inflammatory cytokines, PCT and APACHE Ⅱ has a certain guiding value on sepsis severity evaluation.